Investigation of hepatoprotective effect of aqueous extract of calliste-mon viminalis (AECV) in paracetamol-induced liver toxicity in male rats
Keywords:Aqueous extract of Callistemon viminalis, Hepatoprotective activity, Hepatotoxicity, Paracetamol, liver enzymes
The current study was performed to investigate the hepatoprotective potential of Callistemon viminalis (AECV) on paracetamol –induced liver damage in male rats. Twenty-four male Wister rats (150–200 gm) were divided into 4 groups (6 animals each). Paracetamol was given at a dose of 2g/kg once daily for one week to induce liver injury, while AECV was administered via oral gavage at a dose of 200mg/kg B.W. for 4 weeks. Silymarin was given orally as reference hepatoprotective drug at a dose of 100mg/kg B.W. Liver enzymes such as ALT, AST, ALP, and total bilirubin were used to determine the level of hepatic injury recovery. SOD and CAT were measured as antioxidant enzymes. Both AECV and silymarin were successful in preventing the liver damage caused by paracetamol in male rats. The extract's hepatoprotective properties were demonstrated by a significant decrease in the blood enzymes ALT, AST, ALP, and TB and an increase in the antioxidant enzymes SOD and CAT.
How to Cite
All articles are published under a Creative Commons License and will be directed to the Creative Commons Attribution Non-Commercial (CC BY NC).
The Creative Commons Attribution Non-Commercial License (CC BY NC)permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Use by non-commercial users
For non-commercial and non-promotional purposes individual users may access, download, copy, display and redistribute the articles to colleagues, as well as adapt, translate, text- and data-mine the content subject to the following conditions:
- The authors' moral rights are not compromised. These rights include the right of "paternity" (also known as "attribution" - the right for the author to be identified as such) and "integrity" (the right for the author not to have the work altered in such a way that the author's reputation, or integrity may be impugned).
- Where content in the article is identified as belonging to a third party, it is the obligation of the user to ensure that any reuse complies with the copyright policies of the owner of that content.
- If article content is copied, downloaded, or otherwise reused for non-commercial research and education purposes, a link to the appropriate bibliographic citation (authors, journal, article title, volume, issue, page numbers, DOI and the link to the definitive published version on FSP website) should be maintained.
- Copyright notices and disclaimers must not be deleted.
- Any translations, for which a prior translation agreement with FSP has not been agreed, must prominently display the statement: "This is an unofficial translation of an article that appeared in a FSP publication. The publisher has not endorsed this translation."
Use by commercial "for-profit" organizations
Use of FSP Open Access articles for commercial, promotional, or marketing purposes requires further explicit permission from FSP (firstname.lastname@example.org) and will be subject to a fee.
Commercial purposes include:
Copying or downloading of articles, or linking to such articles for further redistribution, sale or licensing; Copying, downloading or posting by a site or service that incorporates advertising with such content; The inclusion, or incorporation of article content in other works, or services (other than normal quotations with an appropriate citation) that is then available for sale or licensing, for a fee (for example, a compilation produced for marketing purposes, inclusion in a sales pack); Use of article content (other than normal quotations with appropriate citation) by for-profit organizations for promotional purposes; Linking to article content in e-mails redistributed for promotional, marketing or educational purposes; Use for the purposes of monetary reward by means of sale, resale, license, loan, transfer or other form of commercial exploitation such as marketing products; Print reprints of articles can be purchased from email@example.com.
- No special permission is required to reuse all, or part of article published by JKAS, including figures and tables for non-commercial purposes.
- Any part of the article may be reused, non-commercial purposes, without permission provided that the original article is clearly cited.
- Reuse of an article does not imply endorsement by the authors, JKAS