Evaluation bone healing agents: radiological presentative on lidocaine and diclofenac in rabbits

Authors

  • Qamer Jabbar jadoaa Physiology, Biochemistry, and Pharmacology Department, Veterinary Medicine College, Baghdad University, Baghdad, Iraq.
  • Raffal A. Omar Physiology, Biochemistry, and Pharmacology Department, Veterinary Medicine College, Baghdad University, Baghdad, Iraq.

DOI:

https://doi.org/10.59658/jkas.v10i4.1309

Keywords:

Lidocaine hydrochloride, diclofenac, bone healing, rabbit model, radiological analysis, comparative study, intraosseous

Abstract

This study aimed to assess the impact of intraosseous injections of 2% lidocaine hydrochloride and 3.75% Diclofenac on bone regeneration. Forty-five adult male rabbits of a local breed were used to create a 3.5mm hole in the proximal third of the medial aspect of the tibia using an electric drill, with continuous isotonic regular saline irrigation to prevent thermal necrosis. The rabbits were randomly divided into three groups of fifteen each (n=15): a control group without any treatment, Group 1 (Lidocaine HCl), which received a daily dose of 2% lidocaine HCl (2 mg/kg body weight) for five days post-operation (P.O.), and Group 2 (Diclofenac), which received 3.75% Diclofenac (20 mg/kg body weight). Radiographic evaluations were conducted at the end of the 7th, 14th, and 21st days P.O. The findings demonstrated accelerated bone regeneration and development in Group 1 compared to Group 2 and the control group. In conclusion, intraosseous injection of 2% Lidocaine HCl (2mg/kg B.W.) showed a stimulatory effect on bone healing, with osteogenic tissue and trabecular bone formation being visible in radiographic images at the end of the first week, indicating a more effective outcome compared to the Diclofenac and control groups.

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Published

12/15/2023

How to Cite

jadoaa, Q. J. ., & Omar, R. A. . (2023). Evaluation bone healing agents: radiological presentative on lidocaine and diclofenac in rabbits. Journal of Kerbala for Agricultural Sciences, 10(4), 181–194. https://doi.org/10.59658/jkas.v10i4.1309

Issue

Vol. 10 No. 4 (2023): volume 10 issue 4 year 2023

Section

Articles

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