Toxicopathological Effects of Aluminum Chloride (AlCl3) in Reproductive System of Female Albino Mice
DOI:
https://doi.org/10.59658/jkas.v4i5.705Abstract
The present study was designed to investigate the toxic effects of aluminum chloride AlCl3 injected intraperitonally of albino female to study the clinical signs and histopathological changes in reproductive system. (159) of Female mice in the age of puberty and weights ranged (30-35) g were used in this study which included three experiments: first experiment: - This experiment was conducted on 87 female mice, divided into 2 groups by intrapertional injection, the first group contained (15) female mice for the purpose of knowing the lowest value and the highest value in the pilot study, while (72) female mice were used for the purpose of determining the dose toxin medium lethal (LD50), and by the way probit method for the purpose of examining the symptoms of acute toxicity , severity , time of appearance and disappearance clinical sings, which estimated 1100 mg / kg of body weight, second experiment: This experiment was conducted on (36) female mice for a period of (14) days, mice were divided into two groups, as follows: 1- sub acute high toxic exposure group: -Injected with I / P high dose(221.83)mg/kg of body weight included 18 females mice 2-Control group: - Injected I / P solution Physiologic solution included (18) female mice. 3rd experiment: -This experiment was conducted on (36) female mice for a period of (60) day of the experiment, they were divided into two groups, as follows: - 1 – Sub chronic low toxic exposure group: injected I / P low dose (55.45) mg/kg of body weight included (18) females mice. 2– Control group: -injected I / P solution Physiologic and included (18) females mice. The study were conducted at days (3, 7, 14) for the sub acute toxic value exposure and at (15, 30, 60) exposure to toxic sub chronic. The study showed that the effects increased with increasing AlCL3dose and duration of exposure. Where results showed clinical signs that were depression of animal, neurological signs, diarrhea, with paralysis and suffocation and ended up comatose and death within half an hour, pathological changes characterized by degeneration and distraction of ovary with oviduct and uterus, necrosis, papillary hyperplasia of endometrial epithelial lining mostly in sub chronic toxic effects at day 60 .
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2017 Journal of Kerbala for Agricultural Sciences
This work is licensed under a Creative Commons Attribution 4.0 International License.
Licensing Terms
All articles are published under a Creative Commons License and will be directed to the Creative Commons Attribution 4.0 International License That permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Use by non-commercial users
For non-commercial and non-promotional purposes individual users may access, download, copy, display, and redistribute the articles to colleagues, as well as adapt, translate, text- and data-mine the content subject to the following conditions:
- The author's moral rights are not compromised. These rights include the right of "paternity" (also known as "attribution" - the right for the author to be identified as such) and "integrity" (the right for the author not to have the work altered in such a way that the author's reputation, or integrity may be impugned).
- Where content in the article is identified as belonging to a third party, it is the obligation of the user to ensure that any reuse complies with the copyright policies of the owner of that content.
- If article content is copied, downloaded, or otherwise reused for non-commercial research and education purposes, a link to the appropriate bibliographic citation (authors, journal, article title, volume, issue, page numbers, DOI, and the link to the definitive published version on JKAS website) should be maintained.
- Copyright notices and disclaimers must not be deleted.
- Any translations, for which a prior translation agreement with JKAS has not been agreed, must prominently display the statement: "This is an unofficial translation of an article that appeared in an FSP publication. The publisher has not endorsed this translation."
Use by commercial "for-profit" organizations
Use of JKAS Open Access articles for commercial, promotional, or marketing purposes requires further explicit permission from JKAS (journal.agri@uokerbala.edu.iq) and will be subject to a fee.
The commercial purposes include:
Copying or downloading of articles, or linking to such articles for further redistribution, sale, or licensing; Copying, downloading, or posting by a site or service that incorporates advertising with such content; The inclusion, or incorporation of article content in other works, or services (other than normal quotations with an appropriate citation) that is then available for sale or licensing, for a fee (for example, a compilation produced for marketing purposes, inclusion in a sales pack); Use of article content (other than normal quotations with appropriate citation) by for-profit organizations for promotional purposes; Linking to article content in e-mails redistributed for promotional, marketing or educational purposes; Use for the purposes of monetary reward by means of sale, resale, license, loan, transfer or other form of commercial exploitation such as marketing products; Print reprints of articles can be purchased from journal.agri@uokerbala.edu.iq.
Permissions
- No special permission is required to reuse all, or part of the article published by JKAS, including figures and tables for non-commercial purposes.
- Any part of the article may be reused, for non-commercial purposes, without permission provided that the original article is cited.
- Reuse of an article does not imply endorsement by the authors, JKAS
