In vitro antimicrobial studies of new Zn (II) complexes of N- hydroxymethylsaccharin (Sac-CH2OH) and amine ligands

Abstract

A new five Zn(II) complexes of the type [Zn(Sac-CH₂O)₂(N^ÙN)] {where N^ÙN = Bipy, Phen, en, dmen} were prepared from the reaction of diamine ligands N^ÙN with [Zn(Sac-CH₂O)₂] in equivalent molar ratio. The prepared complexes have been characterized by IR, ¹HNMR, elemental analysis, and molar conductivity.

The antimicrobial studies of the Zn(II) complexes were also tested against Escherichia coli, and Pseudomonas aeruginosa, as Gram-negative; Staphylococcus aureus, Salmonella typhi, and Bacillus subtilis, as Gram-positive bacteria . and results suggested that Zn(II) complexes have significant antimicrobial activity.