New Dopamine/Hexamolybdate Nanostructures for Oral Drug Delivery

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Published: Aug 31, 2025
Keywords:
Polyoxometalates (POMs), Dopamine (DA), Temozolomide (TMZ), 3D Nanostructures, Drug Delivery

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Mariam Radhi Kadhim
Department of Chemistry, College of Science, University of Kerbala, Al-Ferahe, Kerbala, Iraq
Ahmed Al-Yasari
School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, NR7 4TJ, UK
Ihsan Mahdi Shaheed
School of Life Sciences, Pharmacy and Chemistry, Kingston University London, Kingston-Upon-Thames KT1 1LQ, Surrey, U.K.
Stephen Barton
School of Life Sciences, Pharmacy and Chemistry, Kingston University London, Kingston-Upon-Thames KT1 1LQ, Surrey, U.K.

Abstract

The synthesis of new 3D nanostructures via the self-assembly of organic-inorganic hybrids from polyoxometalate (POM) Lindqvist-type hexamolybdate with dopamine has been explored. The as-prepared nanostructures were investigated for use as nanocarriers for the drug temozolomide (TMZ), which is used in chemotherapy. The release behavior of TMZ from the nanocarrier at different pHs was studied. The surface morphologies, topographies, and sizes of the nanostructures, as well as their chemical compositions and identities, were investigated via HPLC, FTIR, XRD, SEM, and XPS. The nanocarriers showed an interesting pH-dependent release behavior, indicating the potential for their use in drug delivery systems.

Article Details

Issue
Vol. 1 No. 1 (2025): Journal of Modern Applied Medical Science
Section
Articles