The clinical and Pathological characteristics of Colorectal Cancer in young age group in Karbala province/ Iraq.

Abstract

Abstract

Background: Colorectal cancer (CRC) is a major health problem in Iraq. Aim: to identify the clinicopathological characteristics of colorectal cancer in young Iraqi patients in Karbala. Design of study: Retrospective study was conducted in a single center, Imam AL-Hussein general teaching hospital during the period from January 2009 to April 2017. Patients and Methods: A sample size of 96cases of Colorectal Carcinoma was diagnosed during the study period. The clinic-pathological  parameters were reported. Results: The mean age of the patients was (51.68). There  is a general increase in the incidence of colorectal cancer across the years with percentage of (41.7%) being younger than 45 years. There was slight male predominance. The predominant site of the tumor is colon in (75%) of cases followed by rectum (17.7%). The most common type was adenocarcinoma (82.1%) followed by mucinous type (27.3%), most patients presented with grade I (61.5%).  In the majority of patients the malignancy reaching the pericolic fat (54.5%). About (43.6%) of patients presented with N1 and (50.9%) with stage III followed by stage II in (30.9%). For all cancer grades, the frequency of CRC was higher among patients > 45 years  with the majority of patients with grade III being younger than 45 years and this make a significant difference between both categories,  (P=0.043). With respect to the depth of invasion, those with advance disease (T3), 17 out of 30 cases were younger  than 45 years, thus there was significant difference between 2 age groups. Conclusion: the incidence of colorectal cancer is upgrading in those younger than 45 years.