Correlation between H pylori infection and nonalcoholic fatty liver disease in Karbala city

Abstract

ABSTRACT

B

ACKGROUND.

Nonalcoholic fatty liver disease patients had  higher anti IgG H pylori and might be  a clue that H pylori infection had a strong link  the pathogenesis of early stage NAFLD mostly had simple steatosis . H pylori infection had a role in pathogenesis of insulin resistance and subsequently NAFLD.  H pylori is strong inducer of pro inflammatory cytokine (IL6,IL8,TNF- α  )  .serum triglyceride was higher in H pylori positive group and abnormality in lipid are common in patient with NASH. Recent study have investigated weather H pylori induce insulin resistance mediated through fetuin which decrease in patients with sero positive HpyloriIgG patients.

Patient and method Fifty six patients collect randomly as a case of fatty liver by ultrasound In Imam AL- hussain Medical City in karbala .Obese,DM,alcoholic patients also patients with renal and hepatic diseases were exclude from this study.

Fasting blood sample was taken and send for IgG antibody for H pylori,lipid profile(total cholesterol and triglyceride ,liver function test including ALT and AST.

Result The mean age of patients  was 45+10 and majority 65% was females.

.Sixty seven (67)% of patients who are fatty liver had Hpylori sero positive IgG( p value<0.05).

.Sixty-six(66)% of patients who are fatty liver had normal liver function ALT mean±SD(31±7) and only 34% had increased liver function,ALT meanSD±(110±13) with p value <0.01.

.Seventy-one(71)% of patients who are fatty liver and H pylori sero positive IgG had normal liver function mostly ALT mean±SD(29±10) in comparism with 29% who had increase liver function mostly ALT mean ±SD(98±18) p value <0.01.

Eighty-three(83)% of fatty liver patients had hyperlipidaemia (total cholesterol and triglyceride) mean±SD(290±20),(395±22) respectively  p

value <0.01.

. Seventy-five(75)% of  fatty liver patients with H pylori sero positive IgG had combine hyperlipidaemia (total cholesterol and triglyceride) mean±SD(279±15),(320±20) respectively  p value <0.01.

Conclusion This study shows that there was significant correlation between chronic H pylori  infection and NAFLD .the pathogenic mediator had important role include fetuin-A,TNF-α and adiponectin and on long term IR.