The in-vitro effect of curcumin and arsenic trioxide on the level of NF-kB and induction of apoptosis in B16 cell lines

Authors

  • kamal Abdul Rasool Al-Yasiry

Keywords:

curcumin, arsenic trioxide, NF-kB, flow cytometry, apoptotic cell, B16 cell line

Abstract

Background: Malignant Melanoma (MM) is one of aggressive skin tumors that had increase in incidence during the past two decades. Curcumin is a natural product that had been utilized for a variety of maladies like rheumatic, cardiac, neurological and numerous other disorders while arsenic trioxide ‘ArT’ (not approved for treatment of MM) is well known cytotoxic agent. NF-kB is a specific complicated pertinacious element that participates in controlling of DNA transcription, regulating cytokine expression and, hence, cell survival. It was found that high level of NF-kB is highly associated with occurrence of MM. Induction of programmed cell-death (apoptosis) is another target, through which; destruction of tumor cells can be triggered.

Published

2020-02-18

How to Cite

Al-Yasiry, kamal A. R. (2020). The in-vitro effect of curcumin and arsenic trioxide on the level of NF-kB and induction of apoptosis in B16 cell lines. Karbala Journal of Medicine, 12(2), 2163–2168. Retrieved from https://journals.uokerbala.edu.iq/index.php/kj/article/view/749

Issue

Section

review article