The in-vitro effect of curcumin and arsenic trioxide on the level of NF-kB and induction of apoptosis in B16 cell lines

  • kamal Abdul Rasool Al-Yasiry

Abstract

Background: Malignant Melanoma (MM) is one of aggressive skin tumors that had increase in incidence during the past two decades. Curcumin is a natural product that had been utilized for a variety of maladies like rheumatic, cardiac, neurological and numerous other disorders while arsenic trioxide ‘ArT’ (not approved for treatment of MM) is well known cytotoxic agent. NF-kB is a specific complicated pertinacious element that participates in controlling of DNA transcription, regulating cytokine expression and, hence, cell survival. It was found that high level of NF-kB is highly associated with occurrence of MM. Induction of programmed cell-death (apoptosis) is another target, through which; destruction of tumor cells can be triggered.

Published
2020-02-18
How to Cite
AL-YASIRY, kamal Abdul Rasool. The in-vitro effect of curcumin and arsenic trioxide on the level of NF-kB and induction of apoptosis in B16 cell lines. Kerbala journal of medicine, [S.l.], v. 12, n. 2, p. 2163-2168, feb. 2020. ISSN 1990-5483. Available at: <https://journals.uokerbala.edu.iq/index.php/kj/article/view/749>. Date accessed: 13 july 2020.
Section
review article