TY - JOUR AU - Alfuraiji, Narjes AU - Kadhim, Weam AU - Hameed, Rana AU - Chyad Abdulzahra, Qasim PY - 2022/06/15 Y2 - 2024/03/29 TI - Application of Nano-particulate drug delivery systems to deliver therapeutic agents into cancer cells JF - Karbala Journal of Medicine JA - Karb J Med VL - 14 IS - 2 SE - review article DO - UR - https://journals.uokerbala.edu.iq/index.php/kj/article/view/886 SP - 2496-2512 AB - <p><strong>&nbsp;</strong></p><p><em>Cancer</em> is a disorder in which a group of cells grows uncontrollably, disregarding the cell division's physiological rules. Since its discovery (although the word cancer was not used)3000 BC, extraordinary research aims to uncover novel treatment approaches for combating cancer. Currently, over 60% of all ongoing clinical trials worldwide focus on cancer. The selection of treatment depends on the type of cancer, site, and stage of progression. Surgery, radiation-based surgical knives, chemotherapy, and radiotherapy are traditional treatment approaches that are mostly used. Side effects associated with conventional therapy highlight the need for novel cancer treatment.&nbsp;</p><p>Nanotechnology has been widely investigated and utilized for cancer therapy, as nanoparticles play a key role in medication delivery. Nanoparticle-based drug delivery provides several advantages over traditional drug delivery, including better stability and biocompatibility, increased permeability and retention effect, and precision targeting. It has also been proven to tackle the resistance to anticancer drugs by targeting the underlying mechanism such as overexpression of drug efflux transporters, defective apoptotic pathways, and a hypoxic environment, leading to enhance multidrug resistance reversal. Moreover, nanoparticles' role in immunotherapy is undergoing investigation due to their essential role in cancer treatment. This review highlights the role of nanoparticles for drug delivery in chemotherapy, targeted therapy, and the targeting mechanism of nanoparticle-based drug delivery.</p> ER -