Effect of hypercholestermic diet on the amyloid precursor protein (APP) deposition with some behavior alterations in male rats

Authors

  • Hussein Adnan Raheem Department of Physiology, College of Veterinary Medicine, University of Kerbala, Kerbala, Iraq
  • Wefak Albazi Department of Physiology, College of Veterinary Medicine, University of Kerbala, Kerbala, Iraq.
  • Raeed Altaee Department of Physiology, College of Veterinary Medicine, University of Kerbala, Kerbala, Iraq.
  • Goosoon Hadi Jhoni Department of Family Medicine, College of Medicine, University of Kerbala, Karbala, Iraq.

DOI:

https://doi.org/10.59658/jkas.v10i2.1188

Keywords:

Hypercholesterolemia diet; behavioral alteration; gene expression (APP); Morris water maze (MWM); Elevated plus maze (EPM)

Abstract

Hypercholesterolemic diet (HCD) is unusually high lipid levels in blood and is strongly linked to brain damage and cerebrovascular illnesses. HCD is a chronic brain disorder characterized by cognitive impairment, inflammation, β-amyloid(Aβ) deposition. The goal of this study to investigate behavioral changes caused by the HCD in male rats. The experiment employed sixteen male rats, which was randomly split into two groups, the control group (8/ group) and the treated group (8/ group), which received a 1% cholesterol daily for 28 days. Results of behavioral test showed a significant increase (P≤0.0001) in Morris water maze test (MWM) and Elevated plus-maze test /open arm in treated group compared to control group , while a significant decrease (P≤0.0001) in Elevated plus-maze test / closed arm  treated group  as compared to control group. Fold change comparison between the groups expressed amyloid beta precursor protein (App) gene, this shows significant downregulation of the treatment group compared with control group. We concluded that a HCD has negative behavioral alteration that are linked to gene expression changes.

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Published

06/18/2023

How to Cite

Raheem, H. A. ., Albazi, W. ., Altaee, R. . ., & Jhoni , G. H. . (2023). Effect of hypercholestermic diet on the amyloid precursor protein (APP) deposition with some behavior alterations in male rats. Journal of Kerbala for Agricultural Sciences, 10(2), 58–68. https://doi.org/10.59658/jkas.v10i2.1188

Issue

Vol. 10 No. 2 (2023): Volume 10 Issue 2 2023

Section

Articles

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Copyright (c) 2023 Copyright (c) 2024 is the Author's article. Published by the Journal of Kerbala for Agricultural Sciences under a CC BY 4.0 license

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