Impact of hypercholesterolemic diet on the Ca-regulating hormones and some minerals in male rats

Authors

  • Duaa Raad Abd Al Ameer Physiology Department, College of Veterinary Medicine, University of Kerbela, Kerbela, Iraq.
  • Wefak Albazi Physiology Department, College of Veterinary Medicine, University of Kerbela, Kerbela, Iraq.
  • Hayder Ali muhammed Microbiology Department, Veterinary Medicine College, University of Kerbala, Iraq.

DOI:

https://doi.org/10.59658/jkas.v11i2.1848

Keywords:

Hypercholesterolemic diet; osteoporosis; Ca-regulating hormones; minerals

Abstract

Abstract
Cholesterol is a fatty substance essential for the body. However, excessive amounts can lead to health problems. The study's objective was to investigate the potential effects of a diet high in cholesterol on the hormonal regulation of calcium metabolism and the balance of essential minerals in the body. Twenty male rats aged (1.5-2 ) months were divided as follows, 2 groups : (10) rats were fed a normal diet, and (10) rats were fed a high cholesterol diet(2%) for 8 weeks HCD group. Blood samples were collected after the end of the experiment for physiological and biomarker parameters calculation, as well as lipid profile, minerals, hormones, and antioxidants, after the end of the experiment (8 weeks). The results showed a significant elevation in serum of serum lipid profile (TG, TC, LDL) and decreased (HDL), an elevation in serum of Malondialdehyde and (MDA) and an increase in serum calcium levels. Calcitonin levels, parathyroid hormone, and Vit.D levels showed a significant decrease in serum Glutathione (GSH) levels in the cholesterol group compared to the control group. The study concludes that a hypercholesterolemic diet can lead to Dysregulation of Ca-regulating hormones, Dysregulation of parathyroid hormone (PTH), and Calcitonin, which may disrupt the delicate balance of calcium metabolism in the body. This Dysregulation could result in increased bone resorption, altered calcium absorption and excretion, and imbalances in other minerals involved in bone health and overall physiological processes.

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Published

06/09/2024

How to Cite

Al Ameer , D. R. A. ., Albazi , W. ., & muhammed, H. A. . (2024). Impact of hypercholesterolemic diet on the Ca-regulating hormones and some minerals in male rats. Journal of Kerbala for Agricultural Sciences, 11(2), 62–75. https://doi.org/10.59658/jkas.v11i2.1848

Issue

Vol. 11 No. 2 (2024): The second International Scientific Conference, along with its third periodic session, was held under the theme: "Applied Research and Its Role in Improving Human and Animal Health." The event took place at the College of Veterinary Medicine, University of Karbala, in May 13, 2024.

Section

Articles

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