Atherogenic Indices in Disease Progression of Autosomal Dominant Polycystic Kidney Disease (ADPKD): A Key Role or Standby

Abstract

Background: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the formation of numerous fluid-filled cysts that lead to progressive loss of functional nephrons. Lipids are fundamental building blocks of all cells and play important roles in the pathogenesis of different diseases. Lipid and atherogenic indices as a marker of progression risk has not been previously described in early ADPKD patients with relatively intact kidney function.

Objective: The aim of the study was to determine whether atherogenic indices are indicated for ADPKD progression.

Patients and Methods: A cross-sectional study included 85 ADPKD participants. The study was conducted at kidney diseases consultant of Imam Al-Hassan Al-Mujtaba teaching hospital in Kerbala, Iraq.

Results: The mean of triglycerides was 151.18 mg/dL which indicated a potentially elevated average in such cases. The mean levels of HDL, LDL, VLDL, Non-HDL-C, atherogenic coefficient (AC), and atherogenic index of plasma (AIP) were 38.69 mg/dL, 73.18 mg/dL, 30.32 mg/dL, 104.48 mg/dL, 2.80, and 0.57, respectively. The higher levels of AC and AIP indicate a greater risk of atherosclerosis. The mean level of Castelli I was 3.80 and the mean level of Castelli II was 1.97 with an 2SD of 1.01.

Conclusion: Abnormalities in basic lipid profile tend to be more frequent in ADPKD and it might constitute a major atherogenic risk factor for the development of other diseases