Correlation Between Serum Uric Acid, Vitamin D and HbA1c and the Occurrence of Polycystic Ovarian Syndrome

Abstract

Background: Polycystic ovary syndrome (PCOS) is a global hormonal disorder affect a considerable number of women annually. It is marked by hyperandrogenemia, which is an increase in the production of testosterone in the ovaries, and insulin resistance.

Objectives: The study aimed to determine the interaction between blood level of uric acid, vitamin D, and HbA1C in individuals with polycystic ovarian syndrome.

Materials and Methods: The study utilized patient data from a medical center in Karbala. The data (levels of uric acid, vitamin D, and HbA1C) were collected from medical records for 30 randomly selected female patients diagnosed with polycystic ovarian syndrome. These patients' ages ranged from 18 to 42 years. The data were collected and analyzed statistically by using GRAPH PAD PRISM software.

Results: findings of this study indicate that women diagnosed with polycystic ovarian syndrome had elevated levels of uric acid in their bloodstream (SUA) in comparison to women who do not have polycystic ovary syndrome. The incidence of hyperuricemia in female diagnosed with (PCOS) was significantly high (P value 0.01) compared to normal range. Vitamin D was also significantly more than normal (p value 0.01) while HbA1C was not significantly difference (p value 0.054)

Conclusion: Our findings indicate that women diagnosed with polycystic ovarian syndrome exhibit elevated amounts of vitamin D in their bloodstream, even in patient with normal or overweight. Elevated testosterone levels could potentially enhance vitamin D storage. The findings demonstrated slight non-significant rise in HbA1c levels in relation to body mass index. The findings revealed an increase in uric acid levels in relation to body mass index.