Letrozole Impact on Polycystic Ovarian Syndrome Subfertility Using Sonography and Hormonol Assay

Abstract

Background: One of the main causes of infertility and anovulation is PCOS. the oral aromatase inhibitor letrozole has become a new and promising first-choice treatment for ovulation induction, especially in cases with PCOS and infertility due to effectiveness and acceptable adverse effect profile.

Objective: This clinical trial was intended to evaluate the impact of letrozole administration on the hormones, follicle size, and endometrial thickness among infertile women with PCOS

Patients & Methods

A study at Teba Centre for Infertility involved 100 female patients with PCOS and infertility. Data was collected before and after two months of letrozole administration, using modified Rotterdam criteria and hormone tests.

Results

Remarkable enhancements in the induction of ovulation and the modulation of hormones were noted after letrozole administration. Both follicle size and endometrial thickness increased dramatically. Relationships between the study variables were found by correlation analysis highlighting estrogen significance in differentiating between hormonal alterations.

Conclusion

Letrozole appears to be a promising treatment for infertility, by enhancing the hormonal, besides follicular, and endometrial sonographic features necessary for ovulation and successful pregnancy. To further understand causes and treatment plans, additional research is required.