Evaluation of Cytomegalovirus Infection and Interleukin-33 Levels in Women with Recurrent Pregnancy Loss

Abstract

Background

Recurrent pregnancy loss determine by the "American Society for Reproductive Medicine" and the "European Society of Human Reproduction and Embryology", is defined as two or three clinically identifiable failed pregnancies before twenty to twenty-four weeks of gestation, as confirmed by histopathologic examination or ultrasound. The cytomegalovirus is a member of the Herpesviridae family's Betaherpesvirinae subfamily. It is a common virus that is known to cause congenital infections in infants and in people with weakened immune systems as pregnant. Interleukin 33 (IL-33) a cytokine, is a member of the Interleukin 1 family. bind to the special ST2 receptor.

The aim of study

To determine the unbalanced inflammatory factors such as interleukins 33 (IL-33) and cytomegalovirus infections can be an important factor in recurrent pregnancy loss.

Methods & materials

This study's case-control methodology included 60 Recurent pregnancy loss as case group and 60 healthy controls with successful delivery. IL-33 measure & CMV IgM and IgG from serum blood samples using ELISA technic method.

Results

The obtained results showed that measure of IL-33 in the control was significantly more than case (p = 0.001). cytomegalovirus antibodies in the control were significantly more than case (IgM) (p = 0.01848). & (IgG) (p = 0.00001) , BMI and Age non-significant to link with RPL .

Conclusion

Generally, we showed that the BMI & Age no important role but IL- 33 level and cytomegalovirus infections play an important role in RPL.