Correlation Of IL-5 And IL-17 With Specific Allergens in Pediatric Asthmatic Patients

Abstract

Background: This study aimed to investigate the correlation between interleukin-5 (IL-5) and interleukin-17 (IL-17) with specific aeroallergens in pediatric asthmatic patients.

Patients and Methods: A cross-sectional study included (100) pediatric asthmatic patients, focusing on demographics, Biomarkers, and aeroallergens.

Results: The results showed that eosinophilic asthma patients had considerably higher levels of IL-5 (p=0.0015), especially those who were sensitized to allergens like sorrel, white ash, and sweet vernal mix. IL-17 levels were associated with sensitivity to firebush and CCD indicators and were higher in neutrophilic asthma (p=0.0072). Overlapping biomarker elevations in mixed granulocytic asthma suggested intricate inflammatory processes.

Conclusion: The significance of IL-5 and IL-17 as biomarkers for asthma phenotype in juvenile patients is highlighted by this study. IL-5 plays a crucial role in allergen-induced asthma, as seen by the strong association it has with particular allergens. Asthma treatment could be completely transformed by personalized therapy based on biomarker analysis.