Niosomes As A Drug Delivery System: A Review

Abstract

The invention of advanced drug delivery systems has received a lot of attention in the last few decades. The sophisticated drug delivery systems are designed to meet two requirements: they deliver drugs at a rate determined by the body's needs over the course of therapy, and they deliver the drug directly to inflamed or damaged tissues and/ or organs. Niosome-based drug delivery is one of these systems that encapsulate the medication in a vesicle. The vesicle formed by a bilayer of non-ionic surface-active agents. Niosomes offer promising drug delivery mechanisms. Being of non-ionic materials makes them less risky; hence, increases the therapeutic index of drugs by restricting their action to target cells. The goal of niosomes construction is to control the drug release in a sustained manner, a further change in the distribution profile of drug and targeting to the specific body site. The use of niosomes to encapsulate drugs may improve the protection of peptide-based medications. Insulin-loaded niosomes; for example, have a high tolerance to proteolytic enzymes. They are also effective in the topical delivery due to their ability to prolong the residence time of the drug and its active components in the stratum corneum and epidermis while minimizing systemic absorption.