Influence of Valeriana Officinalis Extract and Zusanli Acupoint Stimulation on Serum ALT and Creatinine Levels in Rats

Abstract

Background

Traditionally used for its calming and antioxidant qualities, Valeriana officinalis has been shown to have beneficial benefits on liver and kidney functioning. Zusanli  is a popular acupuncture point that is frequently linked to immunological and metabolic control. The purpose of this study was to assess how rats. serum levels of creatinine and alanine aminotransferase were affected by Zusanli acupoint stimulation and Valeriana officinalis extract, both separately and in combination. The study focuses on their possible contribution to renal and hepatic function supported.

Methods

Four groups of male Wistar rats were randomly selected, control Zusanli stimulation, Valeriana officinalis extract, and combined treatment, Zusanli was activated by electroacupuncture while the extract was taken orally once a day, Standard enzymatic assays were used to evaluate serum ALT and creatinine levels both prior to and followed the therapy period.

Results

Rats given Valeriana officinalis extract had significantly lower serum ALT levels than the control group,with the combination treatment group showing the biggest drop,The Zusanli stimulation and combined groups had much lower serum creatinine levels,These results show improved biochemical indicators for the liver and kidneys.

Conclusion

This study showed that rats liver and kidney function may be protected by Zusanli acupoint stimulated and Valeriana officinalis extract.The greatest improvement was seen with the combined treatment, indicating a possible synergistic effect.To clarify the underlying mechanisms and therapeutic relevance.