ORAI1 Genetic Polymorphism and its Correlation with Erythropoietin Resistance, Hemoglobin, and Erythropoietin Serum Level in Iraqi Patients with Chronic Renal Failure on Hemodialysis

المؤلفون

  • Farah F. Alsabbagh Pharmacology and Toxicology Department/ Pharmacy College/University of Kerbala
  • Amal Umran Mosa Pharmacology and Toxicology Department/ Pharmacy College/University of Kerbala
  • Abo Almaali H.M Pharmacology and Toxicology Department/ Pharmacy College/University of Kerbala
  • Hassanain Salah Jafer Imam Hussain Medical City

DOI:

https://doi.org/10.62472/kjps.v14.i23.74-83

الكلمات المفتاحية:

Chronic renal failure، ORAI1، Genetic polymorphism، Hemoglobin، Erythropoietin resistance، Hemodialysis

الملخص

Introduction: Chronic renal failure CRF is a widespread, irreversible disease that develops gradually and is classified into five stages depending on the glomerular filtration rate GFR. Anemia is a considerable complication of CRF that becomes serious as GFR decreases, erythropoietin-stimulating agent ESA is used for treating anemia, but the resistance to it stands against its goal in many patients. Studying the genetic polymorphism in one of the erythropoietin-activated pathway store-operated calcium channels SOCs gene is a trial for investigating the cause of resistance.

Method: In this study, 174 subjects were included. Among 112 hemodialysis patients with CRF, 54.5% were non-responders, and the enrolled participants ranged from 20 to 79 years; a single nucleotide polymorphism in the ORAI1 gene was selected. Genotyping was done using an allele-specific polymerase chain reaction technique, and the data was analyzed through the Statistical Package for the Social Sciences.

Results: The results showed that hemoglobin levels differ significantly between the genetic groups, while erythropoietin levels showed no significant variation.

Conclusion: ORAI1 genetic polymorphism has no significant role in erythropoietin resistance in Iraqi hemodialysis patients with CRF, but this genetic variation significantly affects hemoglobin levels, depending on this study.

التنزيلات

منشور

2024-05-27