Synthesis, Characterization and Antibacterial Activity of Surfactants Containing Alkyl-Sugar 1,4-Disubstituted Triazoles
DOI:
https://doi.org/10.62472/kjps.v15.i25.245-257الكلمات المفتاحية:
Surfactants، CUAA cycloaddition reaction، bis -1,2,3-triazole، antibacterial، Escherichia coli، Staphylococcus aureusالملخص
Two surfactants containing alkyl-sugar 1,4-disubstituted triazoles glycoconjugates were synthesized via Cu(I) catalyzed click conditions between azido alkane(C7,C8) and D-mannose based bis –O- propynyl ether. The latter was prepared via Williamson etherification between propargyl bromide and the2C-branched-D-mannose diacetonide which was synthesized in a previous work by aldol condensation between formaldehyde and the protected sugar in MeOH. The two surfactants have been examined in vitro by inhibition of bacteria growth ( Escherichia coli and staphylococcus aureus) and showed a moderate activity. The two prepared surfactants were purified by column chromatography and identified by TLC, FTIR, 1HNMR , 13CNMR, 2D-NMR correlation COSY and HSQC.
