Association Between Serum Level of Interleukin-15 and Severity of Pediatric Asthma

Abstract

Background: A chronic inflammatory process of the airways is a common characteristic of asthma, representing a primary health problem. This disease can infect people of all ages, about 3.5-20 % of the population, but it usually begins in childhood. Objective: To evaluate the relationship between interleukin-15 and pediatric asthma severity.

Methods: The current study is a case-control study that includes 60 asthmatic participants as the patient group and 60 non-asthmatic participants as the control group. Sandwich ELISA using an ELISA kit can be used for the measurement of IL-15 and IgE serum levels. Results: Elevated serum level of IgE in the patients group compared with a control group with significant (P= 0.005) was a result of this study, and there were no significant differences between patients and control about IL- 15 serum levels with (P= 0.968) in asthmatic children.

Conclusions: According to the present study, there was a non-significant association between the severity of asthma and the serum level of IL-15 in children.