Detoxification of Chlordiazepoxide Using Activated Charcoal Prepared from Olive Seeds

Abstract

The study concerns the adsorption of chlordiazepoxide on the olive seeds-activated charcoal (OS-AC). It is carried out to investigate the possible use of OS-AC in the management of chlordiazepoxide intoxication. UV-visible spectrophotometry is applied to measure the concentration, and then it is used to study the adsorption isotherm and the factors influencing it, such as contact time, pH, temperature, ionic strength, and adsorbent dose. The results show that the best contact time is 1 min and 0.1 g dose of adsorbent olive seeds - -activated charcoal with no or small change concerning pH. The study of the adsorbent weight shows an increase in adsorption with an increase in olive seeds-activated charcoal weight. The removal of chlordiazepoxide by using olive seeds-activated charcoal is studied at different temperatures (10C°, 25C°and 50C°) to determine the adsorption isotherms and the thermodynamic functions. The experimental isotherm data are analyzed using Freundlich and Langmuir isotherm models. It is found that Langmuir's isotherm model fits the data very well for the drug chlordiazepoxide on olive seeds activated charcoal. According to Gile's classification, the shapes of the isotherms obtained from experimental data are comparable to the (H - Curve) type. Add the meaning of the abbreviation.