Studying the Correlation Between Serum Hormone Levels in Infertile Women and the Results of IVF and Various Causes of Infertility

Abstract

Background: Infertility is defined as the inability to achieve a clinical pregnancy following 12 months of consistent, unprotected sexual activity.  Both male and female factors, or both, may contribute to infertility. Infertility is most often caused by ovulatory dysfunction, such as inadequate ovarian reserve (POR) and polycystic ovaries (PCO).

Methods: A cross sectional study includes 37 participants. The samples of blood were collected at cycle day two and detected the hormonal levels by MINI VIDAS system.

Results: The result of present study showed that follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in women with female and combined factors with significantly different higher from male and unexplained factors with (p=0.000, p=0.000). While, the level of estradiol (E2), anti-Mullerian hormone (AMH) and Estradiol hormone (E2) at day of human chorionic gonadotropin (HCG) injection in women with male and unexplained factors with significantly different higher from female and combined factors (P=0.007, P=0.000, P=0.003) respectively. While, progesterone in women, there was no significant different between cause of infertility groups with p=0.467. In addition, Total oocyte number, Fertilization rate, Embryo Grade l(GI ), Embryo Grade ll (GII) and transferred embryo of women with unexplained and male factor were significantly different from female and combined factor cases with (P=0.056, P=0.037, P=0.001, p=0.059 and p=0.057) respectively. Regarding the correlation this hormone with pregnancy outcomes, there is no statistical significance.

Conclusion: Serum FSH and LH levels were significantly associated with female and combined factor cases, whereas E2 day2, AMH, and E2 HCG were significantly associated with unexplained and male factor cases.  In terms of progesterone, there was no significant difference between the causes of infertility groups.  Furthermore, the total number of oocytes, fertilization rate, embryo grade l (GI), embryo grade ll (GII), and transferred embryo were all significantly associated with unexplained and male factor cases.  There is no statistical significance to the correlation between these hormones and pregnancy outcomes.