Review on significant monosaccharides-based 1,2,3-triazoles; synthesis and their anticancer activity

Abstract

1,2,3-Triazoles based on carbohydrates have become a promising class of compounds due to their miscellaneous chemical characteristics and their medical applications. A diverse range of carbohydrate scaffolds, such as ribose, glucose, mannose, and galactose, have been employed as precursors to produce a broad spectrum of 1,2,3-triazole derivatives that exhibit improved bioactivity and pharmacokinetic properties. Recent developments in the synthesis and anticancer activity of these derivatives are highlighted in this review. The copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction, which is commonly catalyzed by copper(I) to produce carbohydrate-based 1,2,3-triazoles, providing facile access to structurally diverse to derivatives with a variety of structural properties is also covered. The review also focused on the synthesis of some important sugar-derived azides and terminal alkynes.