Evaluation of the effectiveness of levofloxacins detrimental effects on liver tissues and biochemical markers in male white rats using aqueous ginger extract (Zingiber officinale Rosce)

Abstract

The order to lessen the effects of the antibiotic levofloxacin on male white rats weighing 150–200 g, the study sought to ascertain how well secondary chemicals in the aqueous ginger extract worked. A total of a Thirty dult rats include six equal groups, G 1 as e control. G 2, 3, 4, 5, 6 was dosed with (levofloxacin 16 mg/kg , ginger extract 100 mg/kg + 16 mg/kg , extract ginger 300 mg/kg + 16 mg/kg, extract ginger 100 mg/kg , extract ginger 300 mg/kg) respectively, statistical of results explained a significant p≤ 0.05 with liver weight when comparing the antibiotictreated rats with the control group and other experimental groups. Not significant was showed between groups treated with ginger at concentrations of 100 and 300 mg/kg when compared with others.
Biochemical parameters represented by liver enzymes ALT, AST, and GGT a significant p≤0.05 with treated with levofloxacin, while groups treated with ginger extract did not show any significant difference. As for the histopathological changes, microscopic examination revealed several histopathological changes livers of male rats given levofloxacin treatment compared with control and other groups. However, the histological sections livers treated with the antibiotic + ginger extract at concentrations of 100 and 300 mg/kg did not show histopathological changes, thereby, conclude that aqueous ginger extract at a concentration of 300 mg/kg contributes significantly to minimizing liver damage and preserving the integrity of liver enzymes and cell membranes, whereas 100 mg/kg of ginger extract resulted in very slight cellular alterations.