The physiological effects of orlistat and efficiency extract of cinnamon on body weight and lipid profile in obese male rats
DOI:
https://doi.org/10.59658/jkas.v11i4.2804Keywords:
cinnamon , orlistat , obesity , weight gain , lipid profile , Male Rats.Abstract
The purpose of the current study was to examine the adverse effects of orlistat used alone and in combination with cinnamon with regard to weight gain, body weight percentage, and alterations in the lipid profile in male rats that were obese. Have been selected There were two groups of adult male rats. First experience (induction obesity) for six weeks to induce obesity into (Control group : 10 rats received only rats normal diet without fat as a daily dose) and (High fat diet group : 30 rats received only fed with high-fat diet contain Plate with soy fat and introduce as daily dose) , After this period (six weeks) weight gain and second main groups to ensure the induction , Second experience for six weeks , The treatment period lasted from week 6 to week 12 after confirming the induction of obesity daily oral dosing with the fallowing groups) Control group : 10 rats received only rats normal diet without fat as a daily dose , High fat diet group : 30 rats after induction of obesity divided into the following:-A) Group high fat diet with orlistat 10 rats (10 mg/kg/day). B) Group high fat diet with cinnamon 10 rats (100 mg/kg BW). C) Group high fat diet with orlistat (10 mg/kg/day ) and cinnamon (100 mg/kg BW) 10 rats. The findings show that Weight gain were increase in a significant value (P<0.05) in fat group comparatively to control group and orlistat group , cinnamon group , combination mix group While cholesterol , Triglycerides , LDL-c and VLDL-c were increase in a significant value (P<0.05) while showed a significant (P<0.05) decrease in HDL-c in fat group comparatively to control group and orlistat group , cinnamon group , combination mix group , Conclusions In addition to its ability to inhibit pancreatic lipase, orlistat can also be used to control weight because it indirectly reduces appetite by raising glucagon, IDE, and dopamine levels and by inhibiting the glutamate neurotransmitter. Meanwhile, cinnamon improves blood sugar levels and glycaemic targets.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Copyright (c) 2024 is the Author's article. Published by the Journal of Kerbala for Agricultural Sciences under a CC BY 4.0 license
This work is licensed under a Creative Commons Attribution 4.0 International License.
Licensing Terms
All articles are published under a Creative Commons License and will be directed to the Creative Commons Attribution 4.0 International License (CC BY 4.0) That permits use, distribution, and reproduction in any medium, provided the original work is properly cited. This license also allows the work to be used for commercial purposes.
Use by both non-commercial and commercial users
This content is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) license, permitting use by both non-commercial and commercial users. Individual users may access, download, copy, display, and redistribute the articles to colleagues, as well as adapt, translate, and text- and data-mine the content, subject to the following conditions:
- The author's moral rights, including the right of attribution and the right to protect their work from derogatory treatment, are respected.
- Where content in the article is identified as belonging to a third party, users must ensure that any reuse complies with the copyright policies of the owner of that content.
- If the article content is reused for research or educational purposes, users should maintain a link to the appropriate bibliographic citation, including the DOI and a link to the published version on the journal's website.
