Histological and physiological effects of Sustanon on the liver and Kidneys of male rats
DOI:
https://doi.org/10.59658/jkas.v4i5.686Abstract
This research on male rats was carried out to investigate the possible effects of three different doses of artificial testosterone (Sustanon) on the histology and function of liver and kidneys of adult male rats. In this experiment 48 adult male rats divided into three groups 1, 2 and 3. These groups were injected with0.05, 0.1, 0.2 mg/kg of sustanon respectively for a period of 42 days. Blood samples were collected at the end of the experiment for the determination of the levels of liver enzymes. Male rats were then dissected out, liver and kidneys were removed, weighed and fixed in 10% formalin for histological study, and 12 adult males were used in parallel to these groups as control group. The results showed that there were significant changes in the levels of liver enzymes in all treated groups in comparison with those of the control. All injected groups showed clear histological changes in the basic structure of liver and kidneys in comparison with those for control group. These changes included the increased number of hepatocytes in liver and also some distortion in renal tubules of the kidneys. Changes like cellular hyperplasia and cell degeneration were also observed in all groups of this study especially those of high doses of sustanon. It was concluded from the results of this study that the injection of sustanon at the doses of 0.05, 0.1 and 0.2 mg/ kg in adult male rats had influenced the histological structure of liver and kidneys and also the levels of liver enzymes.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2017 Journal of Kerbala for Agricultural Sciences
This work is licensed under a Creative Commons Attribution 4.0 International License.
Licensing Terms
All articles are published under a Creative Commons License and will be directed to the Creative Commons Attribution 4.0 International License That permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Use by non-commercial users
For non-commercial and non-promotional purposes individual users may access, download, copy, display, and redistribute the articles to colleagues, as well as adapt, translate, text- and data-mine the content subject to the following conditions:
- The author's moral rights are not compromised. These rights include the right of "paternity" (also known as "attribution" - the right for the author to be identified as such) and "integrity" (the right for the author not to have the work altered in such a way that the author's reputation, or integrity may be impugned).
- Where content in the article is identified as belonging to a third party, it is the obligation of the user to ensure that any reuse complies with the copyright policies of the owner of that content.
- If article content is copied, downloaded, or otherwise reused for non-commercial research and education purposes, a link to the appropriate bibliographic citation (authors, journal, article title, volume, issue, page numbers, DOI, and the link to the definitive published version on JKAS website) should be maintained.
- Copyright notices and disclaimers must not be deleted.
- Any translations, for which a prior translation agreement with JKAS has not been agreed, must prominently display the statement: "This is an unofficial translation of an article that appeared in an FSP publication. The publisher has not endorsed this translation."
Use by commercial "for-profit" organizations
Use of JKAS Open Access articles for commercial, promotional, or marketing purposes requires further explicit permission from JKAS (journal.agri@uokerbala.edu.iq) and will be subject to a fee.
The commercial purposes include:
Copying or downloading of articles, or linking to such articles for further redistribution, sale, or licensing; Copying, downloading, or posting by a site or service that incorporates advertising with such content; The inclusion, or incorporation of article content in other works, or services (other than normal quotations with an appropriate citation) that is then available for sale or licensing, for a fee (for example, a compilation produced for marketing purposes, inclusion in a sales pack); Use of article content (other than normal quotations with appropriate citation) by for-profit organizations for promotional purposes; Linking to article content in e-mails redistributed for promotional, marketing or educational purposes; Use for the purposes of monetary reward by means of sale, resale, license, loan, transfer or other form of commercial exploitation such as marketing products; Print reprints of articles can be purchased from journal.agri@uokerbala.edu.iq.
Permissions
- No special permission is required to reuse all, or part of the article published by JKAS, including figures and tables for non-commercial purposes.
- Any part of the article may be reused, for non-commercial purposes, without permission provided that the original article is cited.
- Reuse of an article does not imply endorsement by the authors, JKAS