The Value Diagnostic of Procalcitonin and Complete Blood Count in Patients with Sepsis due to Community -Acquired Pneumonia.

Abstract

Background :Community-acquired pneumonia (CAP) the acute infection of lung tissue in a patient who has acquired it from the community.The most common bacterial pneumonia complications are sepsis .it is a life-threatening organ dysfunction caused by a deregulated host response to infection . Objective : This research aims to to find potential value diagnostic for Procalcitonin (PCT) and Complete Blood Count (CBC) markers, which could provide diagnostic and prognostic value markers for community -acquired pneumonia  and sepsis. Materials and Methods: The samples were (120)  participated  divided into (20) patients of sepsis due  to CAP , (60) patients with  bacterial CAP and (40) control  were collected  blood samples from both males and females patients between the age of (23-95 years) and the average age was (54.9 , 72.5 and 51.4 years) for the three groups  in the study. All the samples were diagnosis by doctor specializing in respiratory and chest diseases, at Imam  Al-Sadiq Hospital in Babylon Governorate, and a doctor specializing in Internal Medicine at Imam  Al-Hussein Medical City in Kerbela Governorate during the period  December 2022 to June 2023. the PCT were estimated by  using automated a combination of Up-converting Phosphor Technology (UPT) and immunochromatography and CBC results by using automated haematology analyzers Sysmex XN -2000. Results: the results  showed high  significant differences regarding most investigated parameters (PCT,WBC, Lym, Mono,Gra , Lym % , Mono%, Gra%, HCT and  N/L ratio .) at P value < 0.000 expect HGB at P  value  < 0.002 and PLT / L  at P value < 0.001 while PLT  there is no significant differences at P value < 0.094 and  also  showed the   PCT, WBC,GRA,GRA % ,N/L ratio and PLT/L ratio were  elevated in patients of CAP and sepsis due to CAP compared to control while reduced  the results of the LYM, LYM %,HGB and HCT  in patients of CAP and sepsis due to CAP compared to control .Conclusion:  Our results showed that PCT ,  WBC , GRA , GRA% ,NLR and PLR were  more valuable marker  for the diagnosis the patients with CAP and Sepsis due to CAP  than other CBC parameters.