Vitamin-D Status in Type 1 Diabetic Children and Teenagers in Karbala, Iraq
Keywords:
Vitamin-D status, T1DM , children and teenagers, Karbala, IraqAbstract
Background: Vitamin-D deficiency now is considered very important subject in clinical endocrinology. Low vitamin-D levels was detected in many metabolic and immune disorders like Diabetes-Mellitus type 1 (T1DM).
Aim: evaluation of vitamin-D status of children & teenagers with T1DM in Karbala, Iraq. Patients and Methods: 171 subject enrolled in case-control study, divided into two groups; diabetic patients 121 cases (48 male and 73 female), aged 5-16 years and the control non diabetic 50 (26 female and 24 male) children with matched age and sex. 25-(OH)D3 measured for all subjects, glycosylated hemoglobin was measured for diabetic cases.
Results: level of vitamin-D was significantly lower for diabetic cases (p=.003). Further analysis of vitamin-D using 10ng/ml as cutoff level to assess vitamin-D severe deficiency between diabetic patients and controls shows that percent of severity of vitamin-D deficiency within diabetic cases (42%) was more than control (12%) which was highly significant.
Conclusion: diabetic children are more susceptible to deficiency of vitamin-D than non-diabetic with more prevalence of severe deficiency among them. measuring of vitamin-D for all T1DM children is recommended.
References
1. Kliegman R, Nelson WE (Waldo E. Nelson textbook of pediatrics. Elsevier/Saunders; 2011. 2610 p.
2. Kappy MS (Michael S, Geffner ME, Allen DB (Pediatric endocrinologist). Pediatric practice. Endocrinology. 482 p.
3. Chakhtoura M, Azar ST. The role of vitamin d deficiency in the incidence, progression, and complications of type 1 diabetes mellitus. International journal of endocrinology. 2013 Mar 13;2013:148673.
4. Ataie-Jafari A, Rahmat A, Abbasi F, Cheong Loke S, Qorbani M, Larijani B. Vitamin D status and associated factors in recent-onset type 1 diabetic children in Iran. Journal of Diabetes & Metabolic Disorders. 2012 Sep 3;11(1):12.
5. Li J, Xiao B, Xiang Y. Immune Function of Vitamin D in Type 1 Diabetes Mellitus. International Journal of Biomedicine. 2014;4(2):67–71.
6. Griz LHM, Bandeira F, Gabbay MAL, Dib SA, Carvalho EF de, Griz LHM, et al. Vitamin D and diabetes mellitus: an update 2013. Arquivos Brasileiros de Endocrinologia & Metabologia. 2014 Feb;58(1):1–8.
7. Savastio S, Cadario F, Genoni G, Bellomo G, Bagnati M, Secco G, et al. Vitamin D Deficiency and Glycemic Status in Children and Adolescents with Type 1 Diabetes Mellitus. Burne THJ, editor. PLOS ONE. 2016 Sep 8;11(9):e0162554.
8. Al Agha AE, Ahmad IA. Association among Vitamin D Deficiency, Type 1 Diabetes Mellitus and Glycemic Control. Journal of Diabetes & Metabolism. 2015 Aug 26;06(09).
9. Littorin B, Blom P, Schölin A, Arnqvist HJ, Blohmé G, Bolinder J, et al. Lower levels of plasma 25-hydroxyvitamin D among young adults at diagnosis of autoimmune type 1 diabetes compared with control subjects: results from the nationwide Diabetes Incidence Study in Sweden (DISS). Diabetologia. 2006 Dec;49(12):2847–52.
10. Janner M, Ballinari P, Mullis P, Flück C. High prevalence of vitamin D deficiency in children and adolescents with type 1 diabetes. Swiss Medical Weekly. 2010 Sep 3;140:w13091.
11. Vojtková J, Ciljaková M, Vojarová L, Jan\’iková K, Michnová Z, Sagiová V. Hypovitaminosis D in children with type 1 diabetes mellitus and its influence on biochemical and densitometric parameters. Acta medica. 2012;55(1):18–22.
12. Aljabri K, Bokhari S, Alqurashi K. Vitamin D Status in Saudi Patients with Type 1 Diabetes Mellitus. 2013;2013(May):137–43.
13. Bin-Abbas BS, Jabari MA, Issa SD, Al-Fares AH, Al-Muhsen S. Vitamin D levels in Saudi children with type 1 diabetes. Saudi Medical Journal. 2011;32(6):589–92.
14. Bener A, Alsaied A, Al-Ali M, Al-Kubaisi A, Basha B, Abraham A, et al. High prevalence of vitamin D deficiency in type 1 diabetes mellitus and healthy children. Acta Diabetologica. 2009 Sep 10;46(3):183–9.
15. Zhang FF, Al Hooti S, Al Zenki S, Alomirah H, Jamil KM, Rao A, et al. Vitamin D deficiency is associated with high prevalence of diabetes in Kuwaiti adults: results from a national survey. BMC Public Health. 2016 Feb;16(1):100.
16. Hassan MM, Alashmawy AA, Sharaf SA, Soliman HM, Fares ZMA, Abuanza IM. Vitamin D Status in Egyptian Children and Adolescents with Type 1 Diabetes Mellitus. Journal of Diabetes & Metabolism. 2015 Jan 15;07(01):2–4.
17. Gomez-Meade C. A., Lopez-Mitnik G. V., Messiah S. E. G-CM. Vitamin D status in children and adolescents with type 1 diabetes in a sun-rich environment. CellR4. 2016;4(5):e2140.
18. Gale EAM, Mathieu C. Vitamin D (revision number 22). In: Diapedia. Diapedia.org; 2013.
19. Slavcheva O, Konstantinova M, Tsakova A, Savova R, Arshinkova M. Levels of 25 (OH) vitamin D in Children and Adolescents with Type 1 Diabetes Mellitus and in Healthy Controls in Bulgarian Population. In: 6th International Conference on Children’s Bone Health Rotterdam, Netherlands. 2013. p. 199.
20. Elsayed AM, Mohamed GA. Vitamin D deficiency and its correlation to hemoglobin A1C in adolescent and young adult type 1 diabetes mellitus patients. Al-Azhar Assiut Medical Journal. 2016;14(2):76–80.
21. Wulandari D, Cahyono HA, Widjajanto E, Puryatni A. Low Levels of Vitamin D correlate with Hemoglobin A1c and Interleukin-10 Levels in Pediatric Type 1 Diabetes Mellitus Patients. The Journal of Tropical Science. 2014;4(3):182–6.
