Shinbone Pain and Fatigue are the Commonest Musculoskeletal Presentation in Vitamin D Deficiency
DOI:
https://doi.org/10.70863/karbalajm.v13i1.765Keywords:
Keywords: Shinbone pain, Fatigue, Musculoskeletal Presentation, Vitamin D Deficiency.Abstract
Abstract
Background: In the past few decades, great attention has been paid to vitamin D deficiency and has been reported to be associated with a growing list of conditions. Nonspecific musculoskeletal manifestations are a common problem in vitamin D deficiency.
The aim of this case series study was to explore the different nonspecific musculoskeletal presentations of this deficiency among adult people.
Patients and methods: A descriptive study was designed to determine the prevalence of nonspecific musculoskeletal symptoms with vitamin D deficiency among adult patients visiting a private clinic in holy Kerbala/ Iraq during two years period.
Result and discussion: Shinbone pain and fatigue were the most prevalent symptoms and showed positive association with vitamin D level. Other symptoms included low backache, proximal muscle ache and knee osteoarthritis. The association of these symptoms with demographic and anthropometric measures were explained. Vitamin D deficiency is a prevalent condition and need to be investigated even in countries with apparently high sun light exposure.
References
References
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10. Heidari B, Heidari P, Hajian-Tilaki K. Association between serum vitamin D deficiency and knee osteoarthritis. International orthopaedics. 2011;35(11):1627-31. (Google Schoolar)
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24. Anoar KA, Amin BAM. Hypo Vitaminosis D in Chronic Muscular Skeletal Pain. Int J Curr Microbiol App Sci. 2015;4(9):696-703.
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27. Heidari B, Heidari P, HajianTilaki K. Relationship between unexplained arthralgia and vitamin D deficiency: a case control study. Acta Medica Iranica. 2014;52(5):400. (Google Schoolar)
28. Straube S, Derry S, Straube C, Moore RA. Vitamin D for the treatment of chronic painful conditions in adults. The Cochrane Library. 2015. (Google Schoolar)
29. Le Goaziou MF, Kellou N, Flori M, Perdrix C, Dupraz C, Bodier E, et al. Vitamin D supplementation for diffuse musculoskeletal pain: Results of a before-and-after study. The European journal of general practice. 2014;20(1):3-9. (Google Schoolar)
30. Schreuder F, Bernsen RM, van der Wouden JC. Vitamin D supplementation for nonspecific musculoskeletal pain in non-Western immigrants: a randomized controlled trial. The Annals of Family Medicine. 2012;10(6):547-55. (Google Schoolar)
31. Al.Araji. Khalid H. AhAAE, ALjanaby. Saba A.R , ALtemmemi. Gazwa S. , ALkhrasni. Rana K. , ALtemmemi. Baidaa I. , ALhadidy Nidal R. , ALkhafaf. Dhamiaa J. , ALhussiny. Shimaa H. , ALganimy. Hawra K. . Prevalence of vitamin D deficiency of females in Karbala, Iraq (Un published study). 2017.
32. Hayder A. Hantoosh MHMBWIAAY. Prevalence of Vitamin D Deficiency in Iraqi Female at Reproductive Age. Medical Journal of Babylon مجلة بابل الطبية. 2019;16(2):119-22.
33. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology & Metabolism. 2011;96(7):1911-30. (Google Schoolar)
34. Beata M-M, Monika L-L, Ewa W. Clinical implications of vitamin D deficiency. Przegląd Menopauzalny. 2015;14(2):75-81 (Google Schoolar).
35. Deurenberg P, Yap M, Van Staveren WA. Body mass index and percent body fat: a meta analysis among different ethnic groups. International journal of obesity. 1998;22(12):1164 -71. (Google Schoolar)
36. Al-Faissaly ADM. Vitamin D Deficiency among Iraqi Females Fifth anuual conference of Imam Hussein Medical City Kerbala/ Iraq2017.
37. Karem KK, Al Mousawi AM, Salih SI. Physiological analysis of vitamin D deficiency in food and its impact on osteoporosis and heredity. EurAsian Journal of BioSciences. 2018;12(2):425-30. (Google Schoolar)
38. Golbahar J, Al-Saffar N, Diab DA, Al-Othman S, Darwish A, Al-Kafaji G. Predictors of vitamin D deficiency and insufficiency in adult Bahrainis: a cross-sectional study. Public health nutrition. 2014;17(4):732-8. (Google Schoolar)
39. Fields J, Trivedi NJ, Horton E, Mechanick JI. Vitamin D in the Persian Gulf: integrative physiology and socioeconomic factors. Current osteoporosis reports. 2011;9(4):243. (Google Schoolar)
40. Survey TCHM. Vitamin D status of Canadians -Results from the Canadian Health Measures Survey. 2013.
41. Janz T, Pearson C. Vitamin D blood levels of Canadians: Statistics Canada Ottawa (Canada); 2013. (Google Schoolar)
42. Jasim HM, Hussein HMA, Al-Kaseer EA. Obesity among females in Al-Sader city Baghdad, Iraq, 2017. Journal of the Faculty of Medicine Baghdad. 2018;60(2):105-7. (Google Schoolar)
43. Mohammed S. Association between Vitamin D and Body Weight in Iraqi Population: Case-Control Study. J Obes Weight Loss Ther. 2018;8(377):2. (Google Schoolar)
44. Turer CB, Lin H, Flores G. Prevalence of vitamin D deficiency among overweight and obese US children. Pediatrics. 2013;131(1):e152-61. (Google Schoolar) (PubMed)
45. Sadaf Alipour AS, Akram Seifollahi, Nooshin Shirzad, Ladan Hosseini,. Risk Factors and Prevalence of Vitamin D Deficiency Among Iranian Women Attending Two University Hospitals, . Iran Red Crescent Med J 2014;16(10):15461(1-4). (Google Schoolar)
46. Snijder MB, van Dam RM, Visser M, Deeg DJ, Dekker JM, Bouter LM, et al. Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women. The Journal of Clinical Endocrinology & Metabolism. 2005;90(7):4119-23. (Google Schoolar)
47. Elspeth E. Shipton EAS. <Vitamin D Deficiency and Pain.pdf>. Pain and Therapy. 2015;4(1):67-87. (Google Schoolar) (PubMed)
48. Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. Jama. 2005;293(18):2257-64. (Google Schoolar) (PubMed)
49. Al Faraj S, Al Mutairi K. Vitamin D deficiency and chronic low back pain in Saudi Arabia. Spine. 2003;28(2):177-9. (Google Schoolar) (PubMed)
50. Warner AE, Arnspiger SA. Diffuse musculoskeletal pain is not associated with low vitamin D levels or improved by treatment with vitamin D. J Clin Rheumatol. 2008;14(1):12-6. (Google Schoolar) (PubMed)
51. Thorneby A, Nordeman LM, Johanson EH. No association between level of vitamin D and chronic low back pain in Swedish primary care: a cross-sectional case-control study. Scand J Prim Health Care. 2016;34(2):196-204. (Google Schoolar)
52. M. Gaikwad SV, M. Mittinity, G. L. Moseley, N. Stocks. <Does vitamin D supplementation alleviate chronic nonspecific musculoskeletal pain.pdf>. Clinical Rheumatology. 2017;36(5):1201-8. (Google Schoolar)
53. Whitehurst JL, Reid CM. Vitamin D deficiency as a cause of chronic pain in the palliative medicine clinic: two case reports. Palliat Med. 2014;28(1):87-9. (Google Schoolar)
54. Kessenich C. <Vitamin D deficiency and leg pain in the elderly.pdf>. The Nurse Practitioner. 2010 35(3):12-3. (Google Schoolar) (PubMed)
55. Peach H, Compston JE, Vedi S, Horton LW. Value of plasma calcium, phosphate, and alkaline phosphatase measurements in the diagnosis of histological osteomalacia. Journal of clinical pathology. 1982;35(6):625-30. (Google Schoolar)
1. Isaacs J. Oxford textbook of rheumatology: Oxford University Press; 2013.(Google Schoolar).
2. Bikle DD. Vitamin D insufficiency/deficiency in gastrointestinal disorders. Journal of Bone and Mineral Research. 2007;22(V50-V54). (Google Schoolar).
3. Mishal AA. Effects of different dress styles on vitamin D levels in healthy young Jordanian women. Osteoporosis International. 2001;12(11):931-5. (Google Schoolar).
4. Meddeb N, Sahli H, Chahed M, Abdelmoula J, Feki M, Salah H, et al. Vitamin D deficiency in Tunisia. Osteoporosis International. 2005;16(2):180-3. (Google Schoolar).
5. Woo J, Lam CW, Leung J, Lau WY, Lau E, Ling X, et al. Very high rates of vitamin D insufficiency in women of child-bearing age living in Beijing and Hong Kong. British Journal of Nutrition. 2008;99(6):1330-4. (Google Schoolar) (PubMed)
6. Mallah EM, Hamad MF, ElManaseer MA, Qinna NA, Idkaidek NM, Arafat TA, et al. Plasma concentrations of 25-hydroxyvitamin D among Jordanians: Effect of biological and habitual factors on vitamin D status. BMC clinical pathology. 2011;11(1):8. (Google Schoolar)
7. Van Dam RM, Snijder MB, Dekker JM, Stehouwer CD, Bouter LM, Heine RJ, et al. Potentially modifiable determinants of vitamin D status in an older population in the Netherlands: the Hoorn Study–. The American journal of clinical nutrition. 2007;85(3):755-61. (Google Schoolar)
8. Heidari B, Javadian Y, Heidari P, Hakimi N, Tilaki KH, Firouzjahi AR. Vitamin D Deficiency is Associated with Nonspecific Low Back Pain in Young Women, a Case-Control Study. 2014. (Google Schoolar)
9. Heidari B, Shirvani JS, Firouzjahi A, Heidari P, Hajian-Tilaki KO. Association between nonspecific skeletal pain and vitamin D deficiency. Int J Rheum Dis. 2010;13(4):340-6. (Google Schoolar)
10. Heidari B, Heidari P, Hajian-Tilaki K. Association between serum vitamin D deficiency and knee osteoarthritis. International orthopaedics. 2011;35(11):1627-31. (Google Schoolar)
11. Alshishtawy MM. <Vitamin D Dificiency This clandestine endemic disease is veiled no more.pdf>. Sultan Qaboos Univ Med J 2012 May; 12(2): . 2012;12(2):140–52. (Google Schoolar) (PubMed)
12. Sahota O. Understanding vitamin D deficiency. Age and ageing. 2014;43(5):589-91. (Google Schoolar) (PubMed)
13. Babaei M, Esmaeili Jadidi M, Heidari B, Gholinia H. Vitamin D deficiency is associated with tibial bone pain and tenderness. A possible contributive role. International journal of rheumatic diseases. 2018. (Google Schoolar) (PubMed)
14. Heidari B, Heidari P, Samari E, Ramzannia Jalali M. Frequency of vitamin D deficiency in common musculo skeletal conditions. Journal of Babol University of Medical Sciences. 2014;16(12):7-15. (Google Schoolar)
15. Heidari B, Mirghassemi MBH. Seasonal variations in serum vitamin D according to age and sex. Caspian journal of internal medicine. 2012;3(4):535. (Google Schoolar)
16. Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, et al. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int. 2009;20(11):1807-20. (Google Schoolar) (PubMed)
17. Alshahrani AA. <Vitamin D Deficiency and Possible Risk Factors Among Middle Easte.pdf>. 2014. (Google Schoolar)
18. Al‐Jarallah K, Shehab D, Abraham M, Mojiminiyi OA, Abdella NA. Musculoskeletal pain: Should physicians test for vitamin D level? International journal of rheumatic diseases. 2013;16(2):193-7. (Google Schoolar)
19. Darwish LAAI. Vitamin D status in healthy female individuals Al-Kufa University Journal for Biology 2018;10(1):11-9.
20. Michael F. Holick MD, Ph.D. <Vitamin-D-deficiency (1).pdf>. 2009. (Google Schoolar)
21. Elamin I.E.; Rashid F. BAMKFA, Al Suwidi H.; . Vitamin D Deficiency, the Volum of the Problem in the Unted Arab Emirates. A Cohort from the Middle East. J Endocrinol Diab;. 2016;3(2):1-5. (Google Schoolar)
22. Arabi A, El Rassi R, El-Hajj Fuleihan G. Hypovitaminosis D in developing countries-prevalence, risk factors and outcomes. Nat Rev Endocrinol. 2010;6(10):550-61. (Google Schoolar)
23. de La Jara GdT, Pecoud A, Favrat B. Female asylum seekers with musculoskeletal pain: the importance of diagnosis and treatment of hypovitaminosis D. BMC family practice. 2006;7(1):4. (Google Schoolar)
24. Anoar KA, Amin BAM. Hypo Vitaminosis D in Chronic Muscular Skeletal Pain. Int J Curr Microbiol App Sci. 2015;4(9):696-703.
25. Abbasi M, Hashemipour S, Hajmanuchehri F, Kazemifar AM. Is vitamin D deficiency associated with non specific musculoskeletal pain? Global journal of health science. 2013;5(1):107. (Google Schoolar)
26. McCarty DE, Reddy A, Keigley Q, Kim PY, Cohen S, Marino AA. Nonspecific pain is a marker for hypovitaminosis D in patients undergoing evaluation for sleep disorders: a pilot study. Nature and science of sleep. 2013;5:37. (Google Schoolar)
27. Heidari B, Heidari P, HajianTilaki K. Relationship between unexplained arthralgia and vitamin D deficiency: a case control study. Acta Medica Iranica. 2014;52(5):400. (Google Schoolar)
28. Straube S, Derry S, Straube C, Moore RA. Vitamin D for the treatment of chronic painful conditions in adults. The Cochrane Library. 2015. (Google Schoolar)
29. Le Goaziou MF, Kellou N, Flori M, Perdrix C, Dupraz C, Bodier E, et al. Vitamin D supplementation for diffuse musculoskeletal pain: Results of a before-and-after study. The European journal of general practice. 2014;20(1):3-9. (Google Schoolar)
30. Schreuder F, Bernsen RM, van der Wouden JC. Vitamin D supplementation for nonspecific musculoskeletal pain in non-Western immigrants: a randomized controlled trial. The Annals of Family Medicine. 2012;10(6):547-55. (Google Schoolar)
31. Al.Araji. Khalid H. AhAAE, ALjanaby. Saba A.R , ALtemmemi. Gazwa S. , ALkhrasni. Rana K. , ALtemmemi. Baidaa I. , ALhadidy Nidal R. , ALkhafaf. Dhamiaa J. , ALhussiny. Shimaa H. , ALganimy. Hawra K. . Prevalence of vitamin D deficiency of females in Karbala, Iraq (Un published study). 2017.
32. Hayder A. Hantoosh MHMBWIAAY. Prevalence of Vitamin D Deficiency in Iraqi Female at Reproductive Age. Medical Journal of Babylon مجلة بابل الطبية. 2019;16(2):119-22.
33. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology & Metabolism. 2011;96(7):1911-30. (Google Schoolar)
34. Beata M-M, Monika L-L, Ewa W. Clinical implications of vitamin D deficiency. Przegląd Menopauzalny. 2015;14(2):75-81 (Google Schoolar).
35. Deurenberg P, Yap M, Van Staveren WA. Body mass index and percent body fat: a meta analysis among different ethnic groups. International journal of obesity. 1998;22(12):1164 -71. (Google Schoolar)
36. Al-Faissaly ADM. Vitamin D Deficiency among Iraqi Females Fifth anuual conference of Imam Hussein Medical City Kerbala/ Iraq2017.
37. Karem KK, Al Mousawi AM, Salih SI. Physiological analysis of vitamin D deficiency in food and its impact on osteoporosis and heredity. EurAsian Journal of BioSciences. 2018;12(2):425-30. (Google Schoolar)
38. Golbahar J, Al-Saffar N, Diab DA, Al-Othman S, Darwish A, Al-Kafaji G. Predictors of vitamin D deficiency and insufficiency in adult Bahrainis: a cross-sectional study. Public health nutrition. 2014;17(4):732-8. (Google Schoolar)
39. Fields J, Trivedi NJ, Horton E, Mechanick JI. Vitamin D in the Persian Gulf: integrative physiology and socioeconomic factors. Current osteoporosis reports. 2011;9(4):243. (Google Schoolar)
40. Survey TCHM. Vitamin D status of Canadians -Results from the Canadian Health Measures Survey. 2013.
41. Janz T, Pearson C. Vitamin D blood levels of Canadians: Statistics Canada Ottawa (Canada); 2013. (Google Schoolar)
42. Jasim HM, Hussein HMA, Al-Kaseer EA. Obesity among females in Al-Sader city Baghdad, Iraq, 2017. Journal of the Faculty of Medicine Baghdad. 2018;60(2):105-7. (Google Schoolar)
43. Mohammed S. Association between Vitamin D and Body Weight in Iraqi Population: Case-Control Study. J Obes Weight Loss Ther. 2018;8(377):2. (Google Schoolar)
44. Turer CB, Lin H, Flores G. Prevalence of vitamin D deficiency among overweight and obese US children. Pediatrics. 2013;131(1):e152-61. (Google Schoolar) (PubMed)
45. Sadaf Alipour AS, Akram Seifollahi, Nooshin Shirzad, Ladan Hosseini,. Risk Factors and Prevalence of Vitamin D Deficiency Among Iranian Women Attending Two University Hospitals, . Iran Red Crescent Med J 2014;16(10):15461(1-4). (Google Schoolar)
46. Snijder MB, van Dam RM, Visser M, Deeg DJ, Dekker JM, Bouter LM, et al. Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women. The Journal of Clinical Endocrinology & Metabolism. 2005;90(7):4119-23. (Google Schoolar)
47. Elspeth E. Shipton EAS. <Vitamin D Deficiency and Pain.pdf>. Pain and Therapy. 2015;4(1):67-87. (Google Schoolar) (PubMed)
48. Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. Jama. 2005;293(18):2257-64. (Google Schoolar) (PubMed)
49. Al Faraj S, Al Mutairi K. Vitamin D deficiency and chronic low back pain in Saudi Arabia. Spine. 2003;28(2):177-9. (Google Schoolar) (PubMed)
50. Warner AE, Arnspiger SA. Diffuse musculoskeletal pain is not associated with low vitamin D levels or improved by treatment with vitamin D. J Clin Rheumatol. 2008;14(1):12-6. (Google Schoolar) (PubMed)
51. Thorneby A, Nordeman LM, Johanson EH. No association between level of vitamin D and chronic low back pain in Swedish primary care: a cross-sectional case-control study. Scand J Prim Health Care. 2016;34(2):196-204. (Google Schoolar)
52. M. Gaikwad SV, M. Mittinity, G. L. Moseley, N. Stocks. <Does vitamin D supplementation alleviate chronic nonspecific musculoskeletal pain.pdf>. Clinical Rheumatology. 2017;36(5):1201-8. (Google Schoolar)
53. Whitehurst JL, Reid CM. Vitamin D deficiency as a cause of chronic pain in the palliative medicine clinic: two case reports. Palliat Med. 2014;28(1):87-9. (Google Schoolar)
54. Kessenich C. <Vitamin D deficiency and leg pain in the elderly.pdf>. The Nurse Practitioner. 2010 35(3):12-3. (Google Schoolar) (PubMed)
55. Peach H, Compston JE, Vedi S, Horton LW. Value of plasma calcium, phosphate, and alkaline phosphatase measurements in the diagnosis of histological osteomalacia. Journal of clinical pathology. 1982;35(6):625-30. (Google Schoolar)
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Published
2020-06-18
How to Cite
abdulhussein, mahdi abdulsahib. (2020). Shinbone Pain and Fatigue are the Commonest Musculoskeletal Presentation in Vitamin D Deficiency. Karbala Journal of Medicine, 13(1), 2301–2309. https://doi.org/10.70863/karbalajm.v13i1.765
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