Association between Helicobacter pylori infection IgG and HbA1c in type 2 diabetes mellitus
Background: Infection with Helicobacter pylori has been recognized as a public health problem worldwide. Patients with diabetes mellitus are more liable to infection. The aim of the study was to determine the association between Helicobacter pylori IgGin type 2 diabetes mellitus in Erbil Cityand to find whether H. pyloriinfection associated with higher levels of glycated hemoglobin (HbA1c).
Materials and Methods: The study was a case-control study and carried out at Laila Kasim Health Centre. Around150 type 2 diabetes mellitus patients and 50 non-diabetic patients wererecruited. The study was conducted between September to November 2020.Blood sampleswere collectedand analyzed for blood sugar, HbA1c and serum used for detection of anti-Helicobacter pylori antibody (IgG) by ELISA.
Results:Helicobacterpylori infection was detected in 73.3% of Type 2 diabetes mellitus (T2DM) patients and54% of controls(P= 0.01). Helicobacter pyloriinfection was highly prevalent in patients with fair control of blood glucose (HbA1c 83.8%; P= 0.007).Helicobacterpylori infection was not associated with; duration of T2DM, age, gender, body mass index (BMI), alcohol consumption,dyspeptic symptoms and level of education.
This study found that the prevalence of H. pylori infection among diabetic patients was significantly higherespecially in those with fair control of blood glucose. This indicates thatH. pyloriinfection could be a potential risk factor for Type 2 Diabetes Mellitus.
Key word: Helicobacterpylori,Type 2 diabetesmellitus, HbA1c.