Remifentanil is more effective than lidocaine in attenuating sympathoadrenal response of endotracheal intubation
Keywords:Remifentanil, lidocaine, endotracheal intubation, hemodynamics
Background: One of the important tasks of anesthetists is controlling the hemodynamic responses (the increase in blood pressure and heart rate) that are associated with direct laryngoscopy and endotracheal intubation. Many medications were tried for this purpose, among them were remifentanil and lidocaine given intravenously after induction of general anesthesia.
Objectives: The aim of the study is to compare these two medications to determine which gives better results.
Material and methods: This is a randomized cross-sectional study which was conducted on 60 clinically fit patients, planned for elective surgery under general anesthesia with endotracheal intubation. Patients were divided randomly into two groups Remifentanil and Lidocaine. Baseline readings of systolic, diastolic blood pressure and heart rate were recorded. General anesthesia was induced using intravenous propofol and rocuronium. The study drug was given and the readings again were recorded after 90 seconds followed by direct laryngoscopy and endotracheal intubation. The third and fourth readings were recorded at one & three minutes postintubation respectively.
Results: Mean systolic blood pressure and heart rate were significantly reduced at time 2 & 3, while mean diastolic blood pressure was significantly reduced at time 2 in remifentanil group compared to lidocaine group.
Conclusion: Remifentanil is more effective than lidocaine in attenuating the sympathoadrenal response of direct laryngoscopy and endotracheal intubation.
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