Toxic Effect of Peganum Harmala L. on Some Physiological Parameters in the Livers of Rabbits

Abstract

In this study, (20) adult male laboratory white rabbits (Lepus arcticus) were used, with an age ranging from eight months to one year. Their weights ranged between  1,500 to 1,600 kg .. It was divided into the first and second group . where the first group included the group injected subcutaneously with the "alcoholic extract"  of Harmala plant seeds with a concentration  3 mg / kg , which included (10) rabbits. The second group was the control, which contained (10) rabbits. In this research, the levels of the AST and ALT enzymes were estimated, and the percentage of some blood proteins such as total protein, albumin, and globulin were measured. Through this study, it was found that:

1- There was a significant increase (P<0.05) in the levels of AST - ALT enzymes compared with the "control group" .

2- There was also a significant decrease ( P<0.05 ) in the average total protein level and the average albumin level compared with the "control group" .

3- No significant differences (P>0.05) were observed in the average globulin level compared with the "control group" .