PVC-Based Ion-Selective Electrode Using Clarithromycin-Bromophenol Blue Ccomplex

Abstract

In this research two electrodes were built using the clarithromycin-bromophenol blue ion pair complex in a PVC matrix and the extraction of clarithromycin from Claricide medication. The experimental section relied on using two plasticizers; tri-butyl phosphate and ortho-nitro-phenyl-octyl ether. The results indicated that slopes and linear ranges of the clarithromycin electrodes [C1 and C2] were 55.699 and 53.895 mV/decade and 10-5-10-2 and 7×10-5-10-2 M, respectively. Based on using TBP plasticizer, the best electrode [C1] had a lifetime of 16 days, a 55.699 mV/decade slope, a 0.9995 correlation coefficient, and 9x10-6M detection limit. Therefore, the main findings of this research indicated that, C1 electrode, which demonstrated excellent stability, can be employed to measure the amount of clarithromycin in drug samples. In addition, the separated and mixed methods can be conducted to study the interference measurements in the presence of certain ions, sucrose, and gelatin in order to determine the selectivity coefficient.