T The Effect Of Serum Leptin Level On Subfertility & obesity in Patient With Polycystic Ovaries In Iraqi Population

Authors

  • zainab ali khaleel iraq

Keywords:

Leptin; Polycystic ovaries; Subfertility

Abstract

Abstract:

Background: Subfertility is an expanding problem in the world influencing about 10-15% of the population. Couples with polycystic ovaries female partner usually have an extra risk of being infertile. For different reasons, polycystic ovaries incident is increasing between females. Adipose tissue is a functional endocrine-like organ, that secretes a variety of cytokines and adipokines(mainly Leptin). Leptin, a hormone that is believed to be released by different cell types (mainly by adipocytes) controls energy stores and reflects body fat stores. Elevated serum level of leptin found to be closely impaired oocyte development.

Aim of the study: To determine the association between serum leptin level and body weight in subfertile women with polycystic ovaries.    

Material and methods: A case-control study was done during the period Sep.2020-Jan.2021.The study includes 88 women whose age range from 18-40 years and their BMI ranging between(18.5-40) Kg/m², 44 of them was infertile with polycystic ovaries, and the other 44 women are fertile women with normal ovarian texture. For both groups, leptin levels were measured.

Result: There is a significant association between serum leptin level and subfertility especially in overweight and obese females compared to the control group.

Conclusions: The significant association between serum leptin levels and reproductive capacity in different bodyweight groups especially in females with polycystic ovaries points to the important function of this adipokine in subfertility pathogenesis especially in overweight and obese females in comparison to the control group.

References

1.Ahrens K, Mumford SL, Schliep KC, Kissell KA, Perkins NJ, Wactawski-Wende J, Schisterman EF. Serum leptin levels and reproductive function during the menstrual cycle. American journal of obstetrics and gynecology. 2014 Mar 1;210(3):248-e1.
2.Baldani DP, Skrgatic L, Kasum M, Zlopasa G, Kralik Oguic S, Herman M. Altered leptin, adiponectin, resistin, and ghrelin secretion may represent an intrinsic polycystic ovary syndrome abnormality. Gynecological Endocrinology. 2019 May 4;35(5):401-5
3.Barbieri RL. Female infertility. Yen and Jaffe's Reproductive Endocrinology 2019 Jan 1, pp (556-581).
4.De Leo V, Musacchio MC, Cappelli V, Massaro MG, Morgante G, Petraglia F. Genetic, hormonal and metabolic aspects of PCOS: an update. Reproductive Biology and Endocrinology. 2016;14(1):38.
5.Eder K, Baffy N, Falus A, Fulop AK. The major inflammatory mediator interleukin-6 and obesity. Inflammation Research. 2009 Nov 1;58(11):727.
6.Fukuda J, Nasu K, Sun B, Shang S, Kawano Y, Miyakawa I. Effects of leptin on the production of cytokines by cultured human endometrial stromal and epithelial cells. Fertility and sterility. 2003 Sep 1;80:783-7.
7.Ganie MA, Vasudevan V, Wani IA, Baba MS, Arif T, Rashid A. Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India. The Indian Journal of Medical Research. 2019 Oct;150(4):333.
8.Silvestris E, de Pergola G, Rosania R, Loverro G. Obesity as a disruptor of the female fertility. Reprod Biol Endocrinol. 2018 Mar 9;16(1):22. DOI: 10.1186/s12958-018-0336-z.
9.Moschos S, Chan JL, Mantzoros CS. Leptin and reproduction: a review. Fertility and sterility. 2002 Mar 1;77(3):433-44.
10.Najmabadi S, Schliep KC, Simonsen SE, Porucznik CA, Egger MJ, Stanford JB. Menstrual bleeding, cycle length, and follicular and luteal phase lengths in women without known subfertility: A pooled analysis of three cohorts. Paediatr Perinat Epidemiol. 2020 May;34(3):318-327. DOI: 10.1111/pp.12644. Epub 2020 Feb 27.
11.Palomba S, Infertility in Women with Polycystic Ovary Syndrome: Pathogenesis and Management. Springer; 2018 Feb 2.p1-100
12.Papadakis M, McPhee S, Rabinow M. Current medical diagnosis & treatment,2020.pp(110-533)
13.Rocha A, Oliveira F, Azevedo R, Silva V, Peres T, Candido A et al. Recent advances in the understanding and management of polycystic ovary syndrome. 2019;8:565.
14.Stelzer I, Zelzer S, Raggam RB, Prüller F, Truschnig-Wilders M, Meinitzer A, Schnedl WJ, Horejsi R, Möller R, Weghuber D, Reeves G. Link between leptin and interleukin-6 levels in the initial phase of obesity related inflammation. Translational Research. 2012 Feb 1;159(2):118-24.
15.Nuttall FQ. Body mass index: obesity, BMI, and health: a critical review. Nutrition today. 2015 May;50(3):117

Published

2021-06-29