A Review of The Relationship Between B Cell Phenotype and Amino Acids in the Development of Chronic Hepatitis B Progression

Abstract

Chronic Hepatitis B (CHB) is still a major global health problem, even though there are vaccines and some antiviral treatments. The virus can stay in the liver for a long time because of its strong genetic material, which helps it escape current treatments. This study is a literature review that looks at how B cells—important immune cells—change during chronic Hepatitis B infection. It focuses on special types of B cells, like atypical memory B cells (AtM B cells) and regulatory B cells (Bregs), and how they may weaken the body’s ability to fight the virus.

The review highlights gaps in current knowledge and suggests that future research should explore new ways to treat Hepatitis B by targeting these B cells. Better understanding of how B cells work in HBV infection may lead to more effective treatments and possibly a functional cure.