Impact of hypercholesterolemic diet on the Ca-regulating hormones and some minerals in male rats

Authors

  • Duaa Raad Abd Al Ameer Physiology Department, College of Veterinary Medicine, University of Kerbela, Kerbela, Iraq.
  • Wefak Albazi Physiology Department, College of Veterinary Medicine, University of Kerbela, Kerbela, Iraq.
  • Hayder Ali muhammed Microbiology Department, Veterinary Medicine College, University of Kerbala, Iraq.

DOI:

https://doi.org/10.59658/jkas.v11i2.1848

Keywords:

Hypercholesterolemic diet; osteoporosis; Ca-regulating hormones; minerals

Abstract

Abstract
Cholesterol is a fatty substance essential for the body. However, excessive amounts can lead to health problems. The study's objective was to investigate the potential effects of a diet high in cholesterol on the hormonal regulation of calcium metabolism and the balance of essential minerals in the body. Twenty male rats aged (1.5-2 ) months were divided as follows, 2 groups : (10) rats were fed a normal diet, and (10) rats were fed a high cholesterol diet(2%) for 8 weeks HCD group. Blood samples were collected after the end of the experiment for physiological and biomarker parameters calculation, as well as lipid profile, minerals, hormones, and antioxidants, after the end of the experiment (8 weeks). The results showed a significant elevation in serum of serum lipid profile (TG, TC, LDL) and decreased (HDL), an elevation in serum of Malondialdehyde and (MDA) and an increase in serum calcium levels. Calcitonin levels, parathyroid hormone, and Vit.D levels showed a significant decrease in serum Glutathione (GSH) levels in the cholesterol group compared to the control group. The study concludes that a hypercholesterolemic diet can lead to Dysregulation of Ca-regulating hormones, Dysregulation of parathyroid hormone (PTH), and Calcitonin, which may disrupt the delicate balance of calcium metabolism in the body. This Dysregulation could result in increased bone resorption, altered calcium absorption and excretion, and imbalances in other minerals involved in bone health and overall physiological processes.

Downloads

Published

06/09/2024

How to Cite

Al Ameer , D. R. A. ., Albazi , W. ., & muhammed, H. A. . (2024). Impact of hypercholesterolemic diet on the Ca-regulating hormones and some minerals in male rats. Journal of Kerbala for Agricultural Sciences, 11(2), 62–75. https://doi.org/10.59658/jkas.v11i2.1848

Issue

Vol. 11 No. 2 (2024): The second International Scientific Conference, along with its third periodic session, was held under the theme: "Applied Research and Its Role in Improving Human and Animal Health." The event took place at the College of Veterinary Medicine, University of Karbala, on May 13, 2024.

Section

Articles

License

Copyright (c) 2024 Journal of Kerbala for Agricultural Sciences

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Licensing Terms

All articles are published under a Creative Commons License and will be directed to the  Creative Commons Attribution 4.0 International License That permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Use by non-commercial users

For non-commercial and non-promotional purposes individual users may access, download, copy, display, and redistribute the articles to colleagues, as well as adapt, translate, text- and data-mine the content subject to the following conditions:

  • The author's moral rights are not compromised. These rights include the right of "paternity" (also known as "attribution" - the right for the author to be identified as such) and "integrity" (the right for the author not to have the work altered in such a way that the author's reputation, or integrity may be impugned).
  • Where content in the article is identified as belonging to a third party, it is the obligation of the user to ensure that any reuse complies with the copyright policies of the owner of that content.
  • If article content is copied, downloaded, or otherwise reused for non-commercial research and education purposes, a link to the appropriate bibliographic citation (authors, journal, article title, volume, issue, page numbers, DOI, and the link to the definitive published version on JKAS website) should be maintained.
  • Copyright notices and disclaimers must not be deleted.
  • Any translations, for which a prior translation agreement with JKAS has not been agreed, must prominently display the statement: "This is an unofficial translation of an article that appeared in an FSP publication. The publisher has not endorsed this translation."

Use by commercial "for-profit" organizations

Use of JKAS Open Access articles for commercial, promotional, or marketing purposes requires further explicit permission from JKAS (journal.agri@uokerbala.edu.iq) and will be subject to a fee.

The commercial purposes include:

Copying or downloading of articles, or linking to such articles for further redistribution, sale, or licensing; Copying, downloading, or posting by a site or service that incorporates advertising with such content; The inclusion, or incorporation of article content in other works, or services (other than normal quotations with an appropriate citation) that is then available for sale or licensing, for a fee (for example, a compilation produced for marketing purposes, inclusion in a sales pack); Use of article content (other than normal quotations with appropriate citation) by for-profit organizations for promotional purposes; Linking to article content in e-mails redistributed for promotional, marketing or educational purposes; Use for the purposes of monetary reward by means of sale, resale, license, loan, transfer or other form of commercial exploitation such as marketing products; Print reprints of articles can be purchased from journal.agri@uokerbala.edu.iq.

Permissions

  • No special permission is required to reuse all, or part of the article published by JKAS, including figures and tables for non-commercial purposes.
  • Any part of the article may be reused, for non-commercial purposes, without permission provided that the original article is cited.
  • Reuse of an article does not imply endorsement by the authors, JKAS

 

Most read articles by the same author(s)