Effect of hypercholestermic diet on the amyloid precursor protein (APP) deposition with some behavior alterations in male rats

Authors

  • Hussein Adnan Raheem Department of Physiology, College of Veterinary Medicine, University of Kerbala, Kerbala, Iraq
  • Wefak Albazi Department of Physiology, College of Veterinary Medicine, University of Kerbala, Kerbala, Iraq.
  • Raeed Altaee Department of Physiology, College of Veterinary Medicine, University of Kerbala, Kerbala, Iraq.
  • Goosoon Hadi Jhoni Department of Family Medicine, College of Medicine, University of Kerbala, Karbala, Iraq.

DOI:

https://doi.org/10.59658/jkas.v10i2.1188

Keywords:

Hypercholesterolemia diet; behavioral alteration; gene expression (APP); Morris water maze (MWM); Elevated plus maze (EPM)

Abstract

Hypercholesterolemic diet (HCD) is unusually high lipid levels in blood and is strongly linked to brain damage and cerebrovascular illnesses. HCD is a chronic brain disorder characterized by cognitive impairment, inflammation, β-amyloid(Aβ) deposition. The goal of this study to investigate behavioral changes caused by the HCD in male rats. The experiment employed sixteen male rats, which was randomly split into two groups, the control group (8/ group) and the treated group (8/ group), which received a 1% cholesterol daily for 28 days. Results of behavioral test showed a significant increase (P≤0.0001) in Morris water maze test (MWM) and Elevated plus-maze test /open arm in treated group compared to control group , while a significant decrease (P≤0.0001) in Elevated plus-maze test / closed arm  treated group  as compared to control group. Fold change comparison between the groups expressed amyloid beta precursor protein (App) gene, this shows significant downregulation of the treatment group compared with control group. We concluded that a HCD has negative behavioral alteration that are linked to gene expression changes.

Downloads

Published

06/18/2023

How to Cite

Raheem, H. A. ., Albazi, W. ., Altaee, R. . ., & Jhoni , G. H. . (2023). Effect of hypercholestermic diet on the amyloid precursor protein (APP) deposition with some behavior alterations in male rats. Journal of Kerbala for Agricultural Sciences, 10(2), 58–68. https://doi.org/10.59658/jkas.v10i2.1188

Issue

Vol. 10 No. 2 (2023): Volume 10 Issue 2 2023

Section

Articles

License

Copyright (c) 2023 Journal of Kerbala for Agricultural Sciences

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Licensing Terms

All articles are published under a Creative Commons License and will be directed to the  Creative Commons Attribution 4.0 International License That permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Use by non-commercial users

For non-commercial and non-promotional purposes individual users may access, download, copy, display, and redistribute the articles to colleagues, as well as adapt, translate, text- and data-mine the content subject to the following conditions:

  • The author's moral rights are not compromised. These rights include the right of "paternity" (also known as "attribution" - the right for the author to be identified as such) and "integrity" (the right for the author not to have the work altered in such a way that the author's reputation, or integrity may be impugned).
  • Where content in the article is identified as belonging to a third party, it is the obligation of the user to ensure that any reuse complies with the copyright policies of the owner of that content.
  • If article content is copied, downloaded, or otherwise reused for non-commercial research and education purposes, a link to the appropriate bibliographic citation (authors, journal, article title, volume, issue, page numbers, DOI, and the link to the definitive published version on JKAS website) should be maintained.
  • Copyright notices and disclaimers must not be deleted.
  • Any translations, for which a prior translation agreement with JKAS has not been agreed, must prominently display the statement: "This is an unofficial translation of an article that appeared in an FSP publication. The publisher has not endorsed this translation."

Use by commercial "for-profit" organizations

Use of JKAS Open Access articles for commercial, promotional, or marketing purposes requires further explicit permission from JKAS (journal.agri@uokerbala.edu.iq) and will be subject to a fee.

The commercial purposes include:

Copying or downloading of articles, or linking to such articles for further redistribution, sale, or licensing; Copying, downloading, or posting by a site or service that incorporates advertising with such content; The inclusion, or incorporation of article content in other works, or services (other than normal quotations with an appropriate citation) that is then available for sale or licensing, for a fee (for example, a compilation produced for marketing purposes, inclusion in a sales pack); Use of article content (other than normal quotations with appropriate citation) by for-profit organizations for promotional purposes; Linking to article content in e-mails redistributed for promotional, marketing or educational purposes; Use for the purposes of monetary reward by means of sale, resale, license, loan, transfer or other form of commercial exploitation such as marketing products; Print reprints of articles can be purchased from journal.agri@uokerbala.edu.iq.

Permissions

  • No special permission is required to reuse all, or part of the article published by JKAS, including figures and tables for non-commercial purposes.
  • Any part of the article may be reused, for non-commercial purposes, without permission provided that the original article is cited.
  • Reuse of an article does not imply endorsement by the authors, JKAS