A Higher Pregnancy Rate with GnRH Antagonist Stimulation Protocol During Intra Cytoplasmic Sperm Injection(ISCI)
Keywords:
GnRH agonist, GnRH antagonist and ICSI outcomeAbstract
Controlled Ovarian Stimulation (COS) is a widely used method during assisted reproduction. The main objective of COS is increasing the quantity of oocytes without compromising their quality. Among different stimulation protocols, there are two commonly used ones: GnRH agonist and GnRH antagonist. Selecting the protocol for COS is the most critical decision could be make and there is no standard protocol which could be applied for all patients.
References
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4. Schoolcraft W, Schlenker T, Gee M, Stevens etal. Improved controlled ovarian hyper stimulation in poor responder in vitro fertilization patients with a micro dose follicle-stimulating hormone flare, growth hormone protocol. Fertil Steril.,1997;67: 93–97.
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6. Surrey ES, Bower J, Hill, Ramsey etal. Clinical and endocrine effects of a micro dose GnRH agonist flare regimen administered to poor responders who are undergoing in vitro fertilization Fertil Steril.,1998;69: 419–424.
7. Kyrou D, Kolibianakis EM, Venetis CA, Papanikolaou etal. How to improve the probability of pregnancy in poor responders undergoing in vitro fertilization: a systematic review and meta-analysis. Fertil Steril.,2009;91:749-66.
8. Alyaa E, Jessica SM, Lawrence E, John etal. Luteal phase estradiol versus luteal phase estradiol and antagonist protocol for controlled ovarian stimulation before in vitro fertilization in poor responders. Fertil Steril .,2011;95:324-326.
9. Ferrari B, Pezzuto A, Barusi L, Coppola F. Gonadotropin releasing hormone antagonists increase follicular fluid insulin-like growth factor-1 and vascular endothelial growth factor during ovarian stimulation cycles. Gynecological Endocrinology.,2006;22(6):289-96.
10. Hernandez ER.Embryo implantation and GnRH-antagonists. Hum Reprod.,2000;15:1211–6.
11. Detti L, Ambler DR, Yelian FD, Kruger etal. Timing and duration of use of GnRH antagonist down-regulation for IVF/ICSI cycles have no impact on oocyte quality or pregnancy outcomes. J Assist Reprod Genet.,2008;25:177–181.
12. Irit G, Nava D. Preparation and evaluation of oocytes for intracytopsmic sperm injection. In : Textbook of assisted reproductive techniques. David K. and Colin M. (eds.).5th ed. CRC Press Taylor & Francis Group.,2018;108-116.
13. Denny S, David K. Evaluation of embryo quality, analysis of morphology and physiology. In : Textbook of assisted reproductive techniques. David K. and Colin M. (eds.).5th ed. CRC Press Taylor & Francis Group.,2018;225-242.
14. Divya S. Review on antagonists. Int. J of Infertility and Fetal Medicine.,2015;6(1):1-10.
15. Bhawana T, Lakhbir D, Shalini G. Effect of GnRH antagonist on follicular development and uterine biophysical profile in controlled ovarian stimulation. Int J Reprod Contracept Obstet Gynecol.,2015; 4(1):157-163.
16. Nikos P, Asimina T, Yannis P, Stella etal. GnRH antagonists and endometrial receptivity in oocyte recipient : a prospective randomized trials. Reroductive BioMedicine Online.,2009;18(2):276-281.
17. Amira B, Salah Z, Hesham A, Abdel Maguid etal. Agonist versus antagonist in ICSI cycles: a randomized trial and cost effectiveness analysis. Middle East Fertility Society Journal.,2005; 10(1).
18. Akman MA, Erden HF, Tosun SB, Bayazit etal. Comparison of agonistic flare-up-protocol and antagonistic multiple dose protocol in ovarian stimulation of poor responders: results of a prospective randomized trial. Hum Reprod., 2011;16 : 868–870.
19. Schmidt DW, Bremner T, Orris JJ, Maier etal. A randomized prospective study of micro dose leuprolide versus ganirelix in in vitro fertilization cycles for poor responders Fertil Steril., 2005;83: 1568–1571.
2. Depalo R, Jayakrishan K, Garruti G, Totaro etal. GnRH agonist versus GnRH antagonist in vitro fertilization and embryo transfer (IVF/ET). Reproductive Biology and Endocrinology.,2012;10:26.
3. Detti L, Williams DB, Robins JC, Maxwell etal. A comparison of three down regulation approaches for poor responders undergoing in vitro fertilization. Fertil Steril.,2005;84:1401–1405.
4. Schoolcraft W, Schlenker T, Gee M, Stevens etal. Improved controlled ovarian hyper stimulation in poor responder in vitro fertilization patients with a micro dose follicle-stimulating hormone flare, growth hormone protocol. Fertil Steril.,1997;67: 93–97.
5. Scott RT, Navot D. Enhancement of ovarian responsiveness with micro doses of gonadotropin-releasing hormone agonist during ovulation induction for in vitro fertilization Fertil Steril.,1994;61: 880–885.
6. Surrey ES, Bower J, Hill, Ramsey etal. Clinical and endocrine effects of a micro dose GnRH agonist flare regimen administered to poor responders who are undergoing in vitro fertilization Fertil Steril.,1998;69: 419–424.
7. Kyrou D, Kolibianakis EM, Venetis CA, Papanikolaou etal. How to improve the probability of pregnancy in poor responders undergoing in vitro fertilization: a systematic review and meta-analysis. Fertil Steril.,2009;91:749-66.
8. Alyaa E, Jessica SM, Lawrence E, John etal. Luteal phase estradiol versus luteal phase estradiol and antagonist protocol for controlled ovarian stimulation before in vitro fertilization in poor responders. Fertil Steril .,2011;95:324-326.
9. Ferrari B, Pezzuto A, Barusi L, Coppola F. Gonadotropin releasing hormone antagonists increase follicular fluid insulin-like growth factor-1 and vascular endothelial growth factor during ovarian stimulation cycles. Gynecological Endocrinology.,2006;22(6):289-96.
10. Hernandez ER.Embryo implantation and GnRH-antagonists. Hum Reprod.,2000;15:1211–6.
11. Detti L, Ambler DR, Yelian FD, Kruger etal. Timing and duration of use of GnRH antagonist down-regulation for IVF/ICSI cycles have no impact on oocyte quality or pregnancy outcomes. J Assist Reprod Genet.,2008;25:177–181.
12. Irit G, Nava D. Preparation and evaluation of oocytes for intracytopsmic sperm injection. In : Textbook of assisted reproductive techniques. David K. and Colin M. (eds.).5th ed. CRC Press Taylor & Francis Group.,2018;108-116.
13. Denny S, David K. Evaluation of embryo quality, analysis of morphology and physiology. In : Textbook of assisted reproductive techniques. David K. and Colin M. (eds.).5th ed. CRC Press Taylor & Francis Group.,2018;225-242.
14. Divya S. Review on antagonists. Int. J of Infertility and Fetal Medicine.,2015;6(1):1-10.
15. Bhawana T, Lakhbir D, Shalini G. Effect of GnRH antagonist on follicular development and uterine biophysical profile in controlled ovarian stimulation. Int J Reprod Contracept Obstet Gynecol.,2015; 4(1):157-163.
16. Nikos P, Asimina T, Yannis P, Stella etal. GnRH antagonists and endometrial receptivity in oocyte recipient : a prospective randomized trials. Reroductive BioMedicine Online.,2009;18(2):276-281.
17. Amira B, Salah Z, Hesham A, Abdel Maguid etal. Agonist versus antagonist in ICSI cycles: a randomized trial and cost effectiveness analysis. Middle East Fertility Society Journal.,2005; 10(1).
18. Akman MA, Erden HF, Tosun SB, Bayazit etal. Comparison of agonistic flare-up-protocol and antagonistic multiple dose protocol in ovarian stimulation of poor responders: results of a prospective randomized trial. Hum Reprod., 2011;16 : 868–870.
19. Schmidt DW, Bremner T, Orris JJ, Maier etal. A randomized prospective study of micro dose leuprolide versus ganirelix in in vitro fertilization cycles for poor responders Fertil Steril., 2005;83: 1568–1571.
Published
2020-02-17
How to Cite
Hassan, M. F. (2020). A Higher Pregnancy Rate with GnRH Antagonist Stimulation Protocol During Intra Cytoplasmic Sperm Injection(ISCI). Karbala Journal of Medicine, 12(2), 2239–2244. Retrieved from https://journals.uokerbala.edu.iq/index.php/kj/article/view/751
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