Histological Influences and Liver Weight Measurements in Female Rats and Their Embryos After Spasmine Drug Administration

الملخص

A study was conducted to determine the role of spasmin in some weight and histological parameters of the livers of pregnant female rats and their fetuses on the nineteenth day of pregnancy. The study was conducted at the College of Education for women at the University of Kufa for the period from January 1- 2022, until June 15- 2022. After obtaining 8 pregnant rats, 4 of them were dosed with a dose of the physiological solution. This group represented the control (G1), while 4 pregnant female rats were dosed with spasmin drug at a dose of (0.48 mg/kg/body weight) (G2) for 19 days. The pregnant rats in the control group were (12) weeks old and weighed (231) grams, while the pregnant animals in the group treated with spasmin were (11) weeks old and weighed (230) grams.

The results of the study recorded a significant decrease (P < 0.05) in the liver weights of both pregnant animals and their fetuses in groups of rats treated with spasmin. The results also showed that treating rats with spasmin until the nineteenth day of pregnancy led to histopathological and abnormal changes in liver tissue such as damage to the central vein wall, hepatocyte necrosis, sinusoidal expansion, hepatic tissue necrosis and inflammatory cell infiltration in pregnant rats and their fetuses compared to pregnant rats and their fetuses in control groups during pregnancy on the nineteenth day.

The study concludes that the treatment with spasming drug reduced the weight of pregnants and embryos’ liver of embryos and also caused various histopathological changes in the structure of the livers of the pregnant rats  and their embryos during the 19th day of gestation.